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SARS-CoV-2 variants and mutational patterns: relationship with risk of ventilator-associated pneumonia in critically ill COVID-19 patients in the era of dexamethasone.
Razazi, Keyvan; Martins Bexiga, Anissa; Arrestier, Romain; Peiffer, Bastien; Voiriot, Guillaume; Luyt, Charles-Edouard; Urbina, Tomas; Mayaux, Julien; Pham, Tài; Roux, Damien; Bellaiche, Raphael; AIt Hamou, Zakaria; Gaudry, Stéphane; Azoulay, Elie; Mekontso Dessap, Armand; Rodriguez, Christophe; Pawlotsky, Jean-Michel; Fourati, Slim; de Prost, Nicolas.
  • Razazi K; Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), 51, Av de Lattre de Tassigny, 94000, Créteil Cedex, France. Keyvan.razazi@aphp.fr.
  • Martins Bexiga A; Groupe de Recherche Clinique CARMAS, Université Paris-Est-Créteil (UPEC), Créteil, France. Keyvan.razazi@aphp.fr.
  • Arrestier R; Université Paris-Est-Créteil (UPEC), Créteil, France. Keyvan.razazi@aphp.fr.
  • Peiffer B; Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), 51, Av de Lattre de Tassigny, 94000, Créteil Cedex, France.
  • Voiriot G; Groupe de Recherche Clinique CARMAS, Université Paris-Est-Créteil (UPEC), Créteil, France.
  • Luyt CE; Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), 51, Av de Lattre de Tassigny, 94000, Créteil Cedex, France.
  • Urbina T; Groupe de Recherche Clinique CARMAS, Université Paris-Est-Créteil (UPEC), Créteil, France.
  • Mayaux J; DMU Medecine, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), Créteil, France.
  • Pham T; Médecine Intensive Réanimation, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Paris, France.
  • Roux D; Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Médecine Intensive Réanimation, and INSERM UMRS_1166-iCAN, Institute of Cardiometabolism and Nutrition, Paris, France.
  • Bellaiche R; Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine, Médecine Intensive Réanimation, 75571, Paris Cedex 12, France.
  • AIt Hamou Z; Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Médecine Intensive Réanimation, Paris, France.
  • Gaudry S; Université Paris-Est-Créteil (UPEC), Créteil, France.
  • Azoulay E; Service de Médecine Intensive-Réanimation, Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, DMU 4 CORREVE Maladies du Cœur et des Vaisseaux, FHU Sepsis, Le Kremlin-Bicêtre, France.
  • Mekontso Dessap A; Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm U1018, Equipe d'Epidémiologie Respiratoire Intégrative, CESP, 94807, Villejuif, France.
  • Rodriguez C; Université de Paris, APHP, Hôpital Louis Mourier, DMU ESPRIT, Service de Médecine Intensive Réanimation, Colombes, France.
  • Pawlotsky JM; Department of Immunology, Infectiology and Hematology, INSERM U1151, CNRS UMR 8253, Institut Necker-Enfants Malades (INEM), Colombes, Paris, France.
  • Fourati S; Département d'Anesthésie Réanimations Chirurgicales, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, France.
  • de Prost N; Médecine Intensive Réanimation, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France.
Sci Rep ; 13(1): 6658, 2023 04 24.
Article in English | MEDLINE | ID: covidwho-2302387
ABSTRACT
We aimed to explore the relationships between specific viral mutations/mutational patterns and ventilator-associated pneumonia (VAP) occurrence in COVID-19 patients admitted in intensive care units between October 1, 2020, and May 30, 2021. Full-length SARS-CoV-2 genomes were sequenced by means of next-generation sequencing. In this prospective multicentre cohort study, 259 patients were included. 222 patients (47%) had been infected with pre-existing ancestral variants, 116 (45%) with variant α, and 21 (8%) with other variants. 153 patients (59%) developed at least one VAP. There was no significant relationship between VAP occurrence and a specific SARS CoV-2 lineage/sublineage or mutational pattern.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Ventilator-Associated / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Variants Limits: Humans Language: English Journal: Sci Rep Year: 2023 Document Type: Article Affiliation country: S41598-023-33639-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Ventilator-Associated / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Variants Limits: Humans Language: English Journal: Sci Rep Year: 2023 Document Type: Article Affiliation country: S41598-023-33639-5