Incidence of congenital complications related to COVID-19 infection during pregnancy.
J Neonatal Perinatal Med
; 16(2): 227-234, 2023.
Article
in English
| MEDLINE | ID: covidwho-2302471
ABSTRACT
PURPOSE:
Infection with COVID-19 during pregnancy has been associated with a hypercoagulable state. It is unknown if maternal COVID-19 infection results in congenital anomalies secondary to intrauterine vascular accidents. This study sought to determine if the rate of in-utero vascular complications (intestinal atresia and limb abnormalities) that may be attributable to the hypercoagulable states associated with COVID-19 and pregnancy increased after the onset of the pandemic.METHODS:
Pregnancy, neonatal, and congenital defect data from a single academic medical center and the partner's children's hospital were collected and compared to the period prior to onset of the pandemic. A subanalysis including pregnant woman 18 years or greater with documented COVID-19 infection during gestation between March 2020-2021 was performed.RESULTS:
Rates of intestinal atresia did not differ prior to or after the onset of the pandemic (3.78% vs 7.23%, pâ=â0.21) nor did rates of limb deficiency disorders (4.41% vs 9.65%, pâ=â0.09). On subanalysis, there were 194 women with COVID-19 infection included inanalysis:
135 (69.6%) were positive during delivery admission and 59 (30.4%) were positive earlier in their pregnancy. There was one infant born with intestinal atresia.CONCLUSION:
We report a low incidence of congenital anomalies in infants born to mothers with COVID-19 infection. It remains unclear if the impact of COVID-19 on the coagulative state augments the normal pro-thrombotic state of pregnancy; ongoing surveillance is warranted.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pregnancy Complications, Infectious
/
COVID-19
/
Intestinal Atresia
Type of study:
Observational study
Limits:
Child
/
Female
/
Humans
/
Infant
/
Infant, Newborn
/
Pregnancy
Language:
English
Journal:
J Neonatal Perinatal Med
Year:
2023
Document Type:
Article
Affiliation country:
NPM-221122
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