CRISPR Technology and Its Importance in SARS-CoV-2 Treatment
Flora
; 28(1):1-10, 2023.
Article
in English
| EMBASE | ID: covidwho-2303110
ABSTRACT
Coronavirus disease-2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) predominantly affects the respiratory system. The COVID-19 pandemic has had devastating effects on the health system and the global economy worldwide. To reduce the worsening impact of the pandemic, various treatment options and vaccines have been developed. Despite these efforts the pandemic could not be stopped because of the single-stranded nature of the virus combined with the lack of proof-reading abilities of the RNA-dependent RNA polymerase (RdRp). This results in a high probability of error in the copying process and consequently, mutations occur. The increase in mutations in SARS-CoV-2 reduced the efficacy of antiviral medicines and vaccines. To fight this problem, studies were conducted on the efficacy and safety of using Clustered Regularly Interspersed Short Palindromic Repeats (CRISPR) in the diagnosis and treatment of COVID-19. Initially, discovered in archaea, CRISPR is a gene-editing tool that works by altering specific parts of the genome. In this review, we focused on the efficacy and safety of CRISPR technology in the treatment of COVID-19.Copyright © 2023 Bilimsel Tip Yayinevi. All rights reserved.
Antiviral drugs; CRISPR-Cas13d; crRNA; Cytotoxicity; SARS-CoV-2; antiviral therapy; clustered regularly interspaced short palindromic repeat; coronavirus disease 2019/dt [Drug Therapy]; coronavirus disease 2019/pc [Prevention]; CRISPR Cas system; disease severity; drug efficacy; drug safety; human; review; vaccination; antivirus agent/dt [Drug Therapy]; DNA vaccine/dt [Drug Therapy]; inactivated virus vaccine/dt [Drug Therapy]; nvx-cov2373 vaccine/dt [Drug Therapy]; RNA vaccine/dt [Drug Therapy]; subunit vaccine/dt [Drug Therapy]
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Flora
Year:
2023
Document Type:
Article
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