Silymarin: A Phytoconstituent with Significant Therapeutic Potential-A Narrative Review
Current Drug Therapy
; 18(2):89-97, 2023.
Article
in English
| Scopus | ID: covidwho-2303573
ABSTRACT
Silymarin, is a phytoactive constituent isolated from the fruits and seeds of Silybum maria-num L Gaetn.), also called milk thistle belonging to the family of Asteracease. The phytoactive has been used to treat several physiological disorders. The objective of this manuscript was to review the therapeutic prospective of silymarin due to its ability to treat several physiological disorders. The da-tabases such as Pubmed, Elsevier, and Google Scholar were reviewed for the investigations or reviews published related to the title. The discussion is focused on the immunomodulatory, chemopreventive, and anti-inflammatory mechanisms of silymarin in various metabolic and dermatological disorders. In addition, the review discusses the different therapeutic potentials of silymarin such as the management of the liver disorder, skin carcinogenesis, cardiovascular disorders, diabetes mellitus, neurodegenera-tive disorders, and several dermatological disorders such as melasma, anti-aging, acne, rosacea, atopic dermatitis, and psoriasis. Silymarin is safe even with a dose higher than the therapeutic dose. Si-lymarin had good potential for the safe and effective treatment of numerous metabolic and dermatological disorders. © 2023 Bentham Science Publishers.
atopic dermatitis; cardiomyopathy; dermatology; liver; silybinin; Silymarin; skin; phytoconstituent; plant medicinal product; silibinin; unclassified drug; acne vulgaris; adverse drug reaction; antiaging activity; antibacterial activity; antiinflammatory activity; antioxidant activity; antiviral activity; carbohydrate metabolism; carcinogenesis; cardiovascular disease; chemical composition; chloasma; coronavirus disease 2019; degenerative disease; diabetes mellitus; drug mechanism; drug therapy; free radical scavenging assay; human; immunomodulation; liver disease; metabolic disorder; pharmacokinetics; psoriasis; Review; rosacea; skin carcinogenesis; skin disease; skin protection; wound healing
Full text:
Available
Collection:
Databases of international organizations
Database:
Scopus
Type of study:
Reviews
Language:
English
Journal:
Current Drug Therapy
Year:
2023
Document Type:
Article
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