PORTAL VEIN THROMBOSIS WHILE TAKING A COMBINED ORAL CONTRACEPTIVE AFTER EXPERIENCED CORONAVIRUS INFECTION.
Akusherstvo i Ginekologiya (Russian Federation)
; 2023(2):165-170, 2023.
Article
in Russian
| EMBASE | ID: covidwho-2303709
ABSTRACT
Background:
Contraceptives are an important component of women's reproductive health care, as they not only reduce the number of unwanted pregnancies, but also improve reproductive function. However, oral contraceptives are known to increase the risk of venous thromboembolism. This risk is increased by infection with the COVID-19 virus that predisposes patients to both venous and arterial thrombosis as a result of excessive inflammation, platelet activation, aggravated endothelial dysfunction, and congestive events. If these patients have hereditary thrombophilia, the risk of venous thromboembolism becomes fatal. Case report The paper describes a clinical case of a patient with total portal vein thrombosis, who have been taking oral contraceptives for a long time and recovering from the novel coronavirus infection. Studying the blood coagulation system and folate cycle genes, by using PCR, has revealed a gene mutation in the plasminogen activator inhibitor (serpine). The authors demonstrate the data of spiral computed tomography of the abdominal organs, as well as changes in laboratory parameters. Conclusion(s) A balanced approach is required when prescribing combined oral contraceptives during the COVID-19 pandemic, especially in women with prothrombotic mutations.Copyright © A group of authors, 2023.
gene polymorphism of the hemostatic system; novel coronavirus infection; oral contraceptives; portal vein thrombosis; abdominal viscera; adult; adverse drug reaction; article; blood clotting; case report; clinical article; coronavirus disease 2019; female; gene mutation; genetic susceptibility; heredity; human; pandemic; polymerase chain reaction; prescription; side effect; spiral computer assisted tomography; thrombophilia; venous thromboembolism; folic acid; oral contraceptive agent; plasminogen activator inhibitor; reserpine
Full text:
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Collection:
Databases of international organizations
Database:
EMBASE
Language:
Russian
Journal:
Akusherstvo i Ginekologiya (Russian Federation)
Year:
2023
Document Type:
Article
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