Association of HLA Class I Genotype with Mortality in Patients with Diabetes Mellitus and COVID-19.
Dokl Biochem Biophys
; 507(1): 289-293, 2022 Dec.
Article
in English
| MEDLINE | ID: covidwho-2303710
ABSTRACT
Numerous studies showed that diabetes mellitus (DM) increases the risk of death from COVID-19 by five times. It is generally accepted that the high lethality of COVID-19 against the background of DM is due to the main complications of this disease micro- and macroangiopathies, as well as heart and kidney failure. In addition, it was shown that acute respiratory viral infection increases the production of interferon gamma, increases muscle resistance to insulin, and modulates the activity of effector CD8+ T cells. The ability of CD8+ T cells to recognize SARS-CoV-2-infected cells depends not only on humoral factors but also on individual genetic characteristics, including the individual set of major histocompatibility complex class I (MHC-I) molecules. In this study, the relationship of the MHC-I genotype of patients with DM aged less than 60 years with the outcome of COVID-19 was studied using a sample of 222 patients. It was shown that lethal outcomes of COVID-19 in patients with DM are associated with the low affinity of the interaction of an individual set of MHC-I molecules with SARS-CoV-2 peptides.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Diabetes Mellitus
/
COVID-19
Type of study:
Prognostic study
Limits:
Humans
/
Middle aged
Language:
English
Journal:
Dokl Biochem Biophys
Journal subject:
Biophysics
/
Biochemistry
Year:
2022
Document Type:
Article
Affiliation country:
S1607672922060114
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