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Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy against SARS-CoV-2 Omicron in macaques.
Solforosi, Laura; Costes, Lea M M; Tolboom, Jeroen T B M; McMahan, Katherine; Anioke, Tochi; Hope, David; Murdza, Tetyana; Sciacca, Michaela; Bouffard, Emily; Barrett, Julia; Wu, Cindy; Hachmann, Nicole; Miller, Jessica; Yu, Jingyou; He, Xuan; Jacob-Dolan, Catherine; Huber, Sietske K Rosendahl; Dekking, Liesbeth; Chamanza, Ronnie; Choi, Ying; Boer, Karin Feddes-de; Barouch, Dan H; Schuitemaker, Hanneke; Zahn, Roland C; Wegmann, Frank.
  • Solforosi L; Janssen Vaccines and Prevention B.V., Leiden, Netherlands. lsolforo@its.jnj.com.
  • Costes LMM; Janssen Vaccines and Prevention B.V., Leiden, Netherlands.
  • Tolboom JTBM; Janssen Vaccines and Prevention B.V., Leiden, Netherlands.
  • McMahan K; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Anioke T; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Hope D; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Murdza T; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Sciacca M; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Bouffard E; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Barrett J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Wu C; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Hachmann N; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Miller J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Yu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • He X; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Jacob-Dolan C; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Huber SKR; Janssen Vaccines and Prevention B.V., Leiden, Netherlands.
  • Dekking L; Janssen Vaccines and Prevention B.V., Leiden, Netherlands.
  • Chamanza R; Non-Clinical Safety Toxicology/Pathology, Janssen Research and Development, Beerse, Belgium.
  • Choi Y; Janssen Vaccines and Prevention B.V., Leiden, Netherlands.
  • Boer KF; Janssen Vaccines and Prevention B.V., Leiden, Netherlands.
  • Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Schuitemaker H; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • Zahn RC; Harvard Medical School, Boston, MA, USA.
  • Wegmann F; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA.
Nat Commun ; 14(1): 1944, 2023 04 07.
Article in English | MEDLINE | ID: covidwho-2304001
ABSTRACT
Omicron spike (S) encoding vaccines as boosters, are a potential strategy to improve COVID-19 vaccine efficacy against Omicron. Here, macaques (mostly females) previously immunized with Ad26.COV2.S, are boosted with Ad26.COV2.S, Ad26.COV2.S.529 (encoding Omicron BA.1 S) or a 11 combination of both vaccines. All booster vaccinations elicit a rapid antibody titers increase against WA1/2020 and Omicron S. Omicron BA.1 and BA.2 antibody responses are most effectively boosted by vaccines including Ad26.COV2.S.529. Independent of vaccine used, mostly WA1/2020-reactive or WA1/2020-Omicron BA.1 cross-reactive B cells are detected. Ad26.COV2.S.529 containing boosters provide only slightly higher protection of the lower respiratory tract against Omicron BA.1 challenge compared with Ad26.COV2.S-only booster. Antibodies and cellular immune responses are identified as complementary correlates of protection. Overall, a booster with an Omicron-spike based vaccine provide only moderately improved immune responses and protection compared with the original Wuhan-Hu-1-spike based vaccine, which still provide robust immune responses and protection against Omicron.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Randomized controlled trials Topics: Vaccines / Variants Limits: Animals / Female / Humans / Male Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2023 Document Type: Article Affiliation country: S41467-023-37715-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Randomized controlled trials Topics: Vaccines / Variants Limits: Animals / Female / Humans / Male Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2023 Document Type: Article Affiliation country: S41467-023-37715-2