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Twenty-Five Year Trend Change in the Etiology of Pediatric Invasive Bacterial Infections in Korea, 1996-2020.
Song, Seung Ha; Lee, Hyunju; Lee, Hoan Jong; Song, Eun Song; Ahn, Jong Gyun; Park, Su Eun; Lee, Taekjin; Cho, Hye-Kyung; Lee, Jina; Kim, Yae-Jean; Jo, Dae Sun; Kim, Jong-Hyun; Kang, Hyun Mi; Lee, Joon Kee; Kim, Chun Soo; Kim, Dong Hyun; Kim, Hwang Min; Choi, Jae Hong; Eun, Byung Wook; Kim, Nam Hee; Cho, Eun Young; Kim, Yun-Kyung; Oh, Chi Eun; Kim, Kyung-Hyo; Ma, Sang Hyuk; Jung, Hyun Joo; Lee, Kun Song; Kim, Kwang Nam; Choi, Eun Hwa.
  • Song SH; Department of Pediatrics, Seoul National University Hospital, Seoul, Korea.
  • Lee H; Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Lee HJ; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
  • Song ES; Department of Pediatrics, Seoul National University Hospital, Seoul, Korea.
  • Ahn JG; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
  • Park SE; Department of Pediatrics, Chonnam National University Medical School, Gwangju, Korea.
  • Lee T; Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • Cho HK; Department of Pediatrics, Pusan National University College of Medicine, Yangsan, Korea.
  • Lee J; Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
  • Kim YJ; Department of Pediatrics, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
  • Jo DS; Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
  • Kim JH; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Kang HM; Department of Pediatrics, Jeonbuk National University Medical School, Jeonju, Korea.
  • Lee JK; Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • Kim CS; Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • Kim DH; Department of Pediatrics, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.
  • Kim HM; Department of Pediatrics, Keimyung University School of Medicine, Daegu, Korea.
  • Choi JH; Department of Pediatrics, Inha University College of Medicine, Incheon, Korea.
  • Eun BW; Department of Pediatrics, Yonsei University Wonju College of Medicine, Wonju, Korea.
  • Kim NH; Department of Pediatrics, Jeju National University School of Medicine, Jeju, Korea.
  • Cho EY; Department of Pediatrics, Eulji University School of Medicine, Nowon Eulji University Hospital, Seoul, Korea.
  • Kim YK; Department of Pediatrics, Inje University Ilsan Paik Hospital, Goyang, Korea.
  • Oh CE; Department of Pediatrics, Chungnam National University Hospital, Daejeon, Korea.
  • Kim KH; Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
  • Ma SH; Department of Pediatrics, Kosin University Gospel Hospital, Busan, Korea.
  • Jung HJ; Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, Korea.
  • Lee KS; Department of Pediatrics, Fatima Hospital, Changwon, Korea.
  • Kim KN; Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
  • Choi EH; Department of Pediatrics, Dankook University College of Medicine, Cheonan, Korea.
J Korean Med Sci ; 38(16): e127, 2023 Apr 24.
Article in English | MEDLINE | ID: covidwho-2304027
ABSTRACT

BACKGROUND:

The coronavirus disease-2019 (COVID-19) pandemic has contributed to the change in the epidemiology of many infectious diseases. This study aimed to establish the pre-pandemic epidemiology of pediatric invasive bacterial infection (IBI).

METHODS:

A retrospective multicenter-based surveillance for pediatric IBIs has been maintained from 1996 to 2020 in Korea. IBIs caused by eight bacteria (Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pyogenes, Listeria monocytogenes, and Salmonella species) in immunocompetent children > 3 months of age were collected at 29 centers. The annual trend in the proportion of IBIs by each pathogen was analyzed.

RESULTS:

A total of 2,195 episodes were identified during the 25-year period between 1996 and 2020. S. pneumoniae (42.4%), S. aureus (22.1%), and Salmonella species (21.0%) were common in children 3 to 59 months of age. In children ≥ 5 years of age, S. aureus (58.1%), followed by Salmonella species (14.8%) and S. pneumoniae (12.2%) were common. Excluding the year 2020, there was a trend toward a decrease in the relative proportions of S. pneumoniae (rs = -0.430, P = 0.036), H. influenzae (rs = -0.922, P < 0.001), while trend toward an increase in the relative proportion of S. aureus (rs = 0.850, P < 0.001), S. agalactiae (rs = 0.615, P = 0.001), and S. pyogenes (rs = 0.554, P = 0.005).

CONCLUSION:

In the proportion of IBIs over a 24-year period between 1996 and 2019, we observed a decreasing trend for S. pneumoniae and H. influenzae and an increasing trend for S. aureus, S. agalactiae, and S. pyogenes in children > 3 months of age. These findings can be used as the baseline data to navigate the trend in the epidemiology of pediatric IBI in the post COVID-19 era.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Bacterial Infections / Meningitis, Bacterial / COVID-19 Type of study: Etiology study / Observational study Topics: Long Covid Limits: Child / Humans / Infant Country/Region as subject: Asia Language: English Journal: J Korean Med Sci Journal subject: Medicine Year: 2023 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Bacterial Infections / Meningitis, Bacterial / COVID-19 Type of study: Etiology study / Observational study Topics: Long Covid Limits: Child / Humans / Infant Country/Region as subject: Asia Language: English Journal: J Korean Med Sci Journal subject: Medicine Year: 2023 Document Type: Article