Protein S Deficiency with Favourable Foetomaternal Outcome: A Case Report
Journal of Clinical and Diagnostic Research
; 17(2):QD04-QD05, 2023.
Article
in English
| EMBASE | ID: covidwho-2304305
ABSTRACT
Protein S is a multifunctional plasma protein, whose deficiency, results in a rare congenital thrombophilia, inherited in an autosomal dominant pattern. It can aggravate the hypercoagulable state of pregnancy, when it presents in parallel with the condition, leading to adverse maternal outcomes and foetal loss. A 35-year-old female third gravida having previous 2 deliveries by Lower Segment Caesarean Section (LSCS) presented to emergency at 10 weeks pregnancy with chief complaints of pain and swelling in left thigh since 4-5 days. After thorough investigations and work-up, the patient was diagnosed with Protein S deficiency. She was managed conservatively and was delivered by elective LSCS with bilateral tubal ligation at 38 weeks of gestation with good foetal and maternal outcomes.The rarity of Protein S deficiency along with the successful outcome of the pregnancy makes this a unique case.Copyright © 2023 Journal of Clinical and Diagnostic Research. All rights reserved.
Plasmaprotein; Pregnancy; Thrombophilia; abdomen; abdominal tenderness; adult; anticoagulant therapy; Apgar score; article; bleeding time; blood clotting disorder; blood clotting time; breathing rate; case report; cesarean section; clinical article; color Doppler flowmetry; coronavirus disease 2019; deep vein thrombosis; echography; female; follow up; hemodynamics; human; maternal fetal transmission; menstrual cycle; middle aged; outcome assessment; oxygen saturation; pain; protein S deficiency/di [Diagnosis]; recanalization; swelling; thigh; uterine tube ligation; antinuclear antibody/ec [Endogenous Compound]; cardiolipin antibody/ec [Endogenous Compound]; D dimer/ec [Endogenous Compound]; low molecular weight heparin; lupus anticoagulant/ec [Endogenous Compound]; phospholipid antibody/ec [Endogenous Compound]; pregnancy specific beta1 glycoprotein/ec [Endogenous Compound]; protein C/ec [Endogenous Compound]; protein S/ec [Endogenous Compound]
Full text:
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Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Case report
/
Prognostic study
Language:
English
Journal:
Journal of Clinical and Diagnostic Research
Year:
2023
Document Type:
Article
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