Long COVID: pathophysiological factors and abnormalities of coagulation.
Trends Endocrinol Metab
; 34(6): 321-344, 2023 06.
Article
in English
| MEDLINE | ID: covidwho-2304975
ABSTRACT
Acute COVID-19 infection is followed by prolonged symptoms in approximately one in ten cases known as Long COVID. The disease affects ~65 million individuals worldwide. Many pathophysiological processes appear to underlie Long COVID, including viral factors (persistence, reactivation, and bacteriophagic action of SARS CoV-2); host factors (chronic inflammation, metabolic and endocrine dysregulation, immune dysregulation, and autoimmunity); and downstream impacts (tissue damage from the initial infection, tissue hypoxia, host dysbiosis, and autonomic nervous system dysfunction). These mechanisms culminate in the long-term persistence of the disorder characterized by a thrombotic endothelialitis, endothelial inflammation, hyperactivated platelets, and fibrinaloid microclots. These abnormalities of blood vessels and coagulation affect every organ system and represent a unifying pathway for the various symptoms of Long COVID.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Thrombosis
/
COVID-19
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Trends Endocrinol Metab
Journal subject:
Endocrinology
/
Metabolism
Year:
2023
Document Type:
Article
Affiliation country:
J.tem.2023.03.002
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