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Sex and age affect acute and persisting COVID-19 illness.
Vasilevskaya, Anna; Mushtaque, Asma; Tsang, Michelle Y; Alwazan, Batoul; Herridge, Margaret; Cheung, Angela M; Tartaglia, Maria Carmela.
  • Vasilevskaya A; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
  • Mushtaque A; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
  • Tsang MY; Division of Neurology, Toronto Western Hospital, University Health Network, 399 Bathurst St. WW5-449, Toronto, ON, M5T 2S8, Canada.
  • Alwazan B; Krembil Research Institute, University Health Network, Toronto, ON, Canada.
  • Herridge M; Division of Neurology, Toronto Western Hospital, University Health Network, 399 Bathurst St. WW5-449, Toronto, ON, M5T 2S8, Canada.
  • Cheung AM; Krembil Research Institute, University Health Network, Toronto, ON, Canada.
  • Tartaglia MC; Division of Neurology, Toronto Western Hospital, University Health Network, 399 Bathurst St. WW5-449, Toronto, ON, M5T 2S8, Canada.
Sci Rep ; 13(1): 6029, 2023 04 13.
Article in English | MEDLINE | ID: covidwho-2305181
ABSTRACT
Long COVID is associated with neurological and neuropsychiatric manifestations. We conducted an observational study on 97 patients with prior SARS-CoV-2 infection and persisting cognitive complaints that presented to the University Health Network Memory Clinic between October 2020 and December 2021. We assessed the main effects of sex, age, and their interaction on COVID-19 symptoms and outcomes. We also examined the relative contribution of demographics and acute COVID-19 presentation (assessed retrospectively) on persistent neurological symptoms and cognition. Among our cohort, males had higher hospitalization rates than females during the acute COVID-19 illness (18/35 (51%) vs. 15/62 (24%); P = .009). Abnormal scores on cognitive assessments post-COVID were associated with older age (AOR = 0.84; 95% CI 0.74-0.93) and brain fog during initial illness (AOR = 8.80; 95% CI 1.76-65.13). Female sex (ARR = 1.42; 95% CI 1.09-1.87) and acute shortness of breath (ARR = 1.41; 95% CI 1.09-1.84) were associated with a higher risk of experiencing more persistent short-term memory symptoms. Female sex was the only predictor associated with persistent executive dysfunction (ARR = 1.39; 95% CI 1.12-1.76) and neurological symptoms (ARR = 1.66; 95% CI 1.19-2.36). Sex differences were evident in presentations and cognitive outcomes in patients with long COVID.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans / Male Language: English Journal: Sci Rep Year: 2023 Document Type: Article Affiliation country: S41598-023-33150-x

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans / Male Language: English Journal: Sci Rep Year: 2023 Document Type: Article Affiliation country: S41598-023-33150-x