Chimeric antigen receptor-based therapies beyond cancer.
Eur J Immunol
; 53(3): e2250184, 2023 03.
Article
in English
| MEDLINE | ID: covidwho-2305222
ABSTRACT
Adoptive cell transfer (ACT) therapies have gained renewed interest in the field of immunotherapy following the advent of chimeric antigen receptor (CAR) technology. This immunological breakthrough requires immune cell engineering with an artificial surface protein receptor for antigen-specific recognition coupled to an intracellular protein domain for cell activating functions. CAR-based ACT has successfully solved some hematological malignancies, and it is expected that other tumors may soon benefit from this approach. However, the potential of CAR technology is such that other immune-mediated disorders are beginning to profit from it. This review will focus on CAR-based ACT therapeutic areas other than oncology such as infection, allergy, autoimmunity, transplantation, and fibrotic repair. Herein, we discuss the results and limitations of preclinical and clinical studies in that regard.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Hematologic Neoplasms
/
Receptors, Chimeric Antigen
/
Neoplasms
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Eur J Immunol
Year:
2023
Document Type:
Article
Affiliation country:
Eji.202250184
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