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Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation.
Wang, Desheng; Gomes, Marta T; Mo, Yanfei; Prohaska, Clare C; Zhang, Lu; Chelvanambi, Sarvesh; Clauss, Matthias A; Zhang, Dongfang; Machado, Roberto F; Gao, Mingqi; Bai, Yang.
  • Wang D; Department of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
  • Gomes MT; Division of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, IN 46202, USA.
  • Mo Y; Department of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
  • Prohaska CC; Division of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, IN 46202, USA.
  • Zhang L; Department of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
  • Chelvanambi S; Division of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, IN 46202, USA.
  • Clauss MA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Zhang D; Division of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, IN 46202, USA.
  • Machado RF; Department of Pharmacognosy, School of Pharmacy, China Medical University, Shenyang 110122, China.
  • Gao M; Division of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, IN 46202, USA.
  • Bai Y; Department of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Int J Mol Sci ; 24(8)2023 Apr 18.
Article in English | MEDLINE | ID: covidwho-2305448
ABSTRACT
Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by the progressive elevation of pulmonary arterial pressures. It is becoming increasingly apparent that inflammation contributes to the pathogenesis and progression of PAH. Several viruses are known to cause PAH, such as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), human endogenous retrovirus K(HERV-K), and human immunodeficiency virus (HIV), in part due to acute and chronic inflammation. In this review, we discuss the connections between HERV-K, HIV, SARS-CoV-2, and PAH, to stimulate research regarding new therapeutic options and provide new targets for the treatment of the disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV Infections / Endogenous Retroviruses / Pulmonary Arterial Hypertension / COVID-19 Limits: Humans Language: English Year: 2023 Document Type: Article Affiliation country: Ijms24087472

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Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV Infections / Endogenous Retroviruses / Pulmonary Arterial Hypertension / COVID-19 Limits: Humans Language: English Year: 2023 Document Type: Article Affiliation country: Ijms24087472