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Autocrine, Paracrine, and Endocrine Signals That Can Alter Alveolar Macrophages Function.
Yang, Yue; Wang, Yun.
  • Yang Y; Department of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang, Liaoning, People's Republic of China.
  • Wang Y; Department of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang, Liaoning, People's Republic of China. ywang28@cmu.edu.cn.
Rev Physiol Biochem Pharmacol ; 2022 Dec 07.
Article in English | MEDLINE | ID: covidwho-2306070
ABSTRACT
Alveolar macrophages (AMs) are extremely versatile cells with complex functions involved in health or diseases such as pneumonia, asthma, and pulmonary alveolar proteinosis. In recent years, it has been widely identified that the different functions and states of macrophages are the results from the complex interplay between microenvironmental signals and macrophage lineage. Diverse and complicated signals to which AMs respond are mentioned when they are described individually or in a particular state of AMs. In this review, the microenvironmental signals are divided into autocrine, paracrine, and endocrine signals based on their secreting characteristics. This new perspective on classification provides a more comprehensive and systematic introduction to the complex signals around AMs and is helpful for understanding the roles of AMs affected by physiological environment. The existing possible treatments of AMs are also mentioned in it. The thorough understanding of AMs signals modulation may be contributed to the development of more effective therapies for AMs-related lung diseases.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Systematic review/Meta Analysis Language: English Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Systematic review/Meta Analysis Language: English Year: 2022 Document Type: Article