Liver injury due to COVID-19 in critically ill adult patients. A retrospective study.
Rev Gastroenterol Mex (Engl Ed)
; 2023 Apr 18.
Article
in English
| MEDLINE | ID: covidwho-2307255
ABSTRACT
INTRODUCTION AND AIM:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged, causing the current pandemic of acute respiratory disease known as COVID-19. Liver injury due to COVID-19 is defined as any liver injury occurring during the course of the disease and treatment of patients with COVID-19, with or without liver disease. The incidence of elevated liver transaminases, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), ranges from 2.5 to 76.3%. The aim of the present study was to describe the hepatic biochemical abnormalities, after a SARS-CoV-2-positive polymerase chain reaction (PCR) test, and the mortality rate in critically ill patients. MATERIALS ANDMETHODS:
A retrospective study was conducted that included 70 patients seen at a private hospital in Mexico City, within the time frame of February-December 2021. Median patient age was 44.5 years (range 37-57.2) and 43 (61.4%) of the patients were men. Liver function tests were performed on the patients at hospital admission.RESULTS:
Gamma glutamyl transferase (GGT) levels were elevated (pâ¯=â¯0.032), as were those of AST (pâ¯=â¯0.011) and ALT (pâ¯=â¯0.021). The patients were stratified into age groups 18-35, 36-50, and > 50 years of age. The 18 to 35-year-olds had the highest liver enzyme levels and transaminase levels were higher, the younger the patient. Due to the low mortality rate (one patient whose death did not coincide with a hepatic cause), the multivariate analysis showed an R2 association of 0.689, explained by AST, GGT, and C-reactive protein levels.CONCLUSIONS:
Despite the increase in transaminases in our study population during the course of COVID-19, there was no increase in mortality. Nevertheless, hospitalized patient progression should be continuously followed.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Language:
English
Year:
2023
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS