New Nickel (II), Copper (II) and Cobalt (II) Complexes Based Salicyaldehyde Schiff Base: Synthesis, Characterisation, and Antiviral Activity

ABSTRACT

The three metal complexes were synthesized from schiff base which were formed by condensation of salicyaldehyde and 4-chlorophenylethanaamine. The spectral characterisation is done by UV–Vis., 1H NMR and LCMS. The spectroscopic results evidenced the interaction of the ligands and their Nickel (II), Cobalt (II) and Copper (II) complexes. Antivirals are medicines that help stop a virus infecting healthy cells or multiplying in body. Metal–organic frameworks (MOFs) combined with bio macromolecules, viruses and cells have emerged as novel bio composites for application to drug delivery, bio sensing, bio specimen preservation, and cell and virus manipulation These synthesized compounds have been screened for antiviral activity (covid virus, hepatitis B virus) strains by using dics diffusion method. Antiviral medicines target the virus (SARS-CoV-2) that causes COVID-19 to prevent it infecting healthy cells in your body and multiplying. The antiviral activity of synthesized Schiff bases and metal complexes exhibited moderate degrees of inhibitory effects. Among these, complex 3 show better activity toward covid virus and hepatitis virus. It was found that complex 3 displayed higher antiviral activity than Schiff base ligand (L-1) compared with the Acyclovir used as standard.