Clinical characteristics and comorbidities associated with SARS-CoV-2 breakthrough infection in the University of California Healthcare Systems.
Am J Med Sci
; 366(2): 102-113, 2023 08.
Article
in English
| MEDLINE | ID: covidwho-2308923
ABSTRACT
BACKGROUND:
To evaluate the degree to which clinical comorbidities or combinations of comorbidities are associated with SARS-CoV-2 breakthrough infection. MATERIALS ANDMETHODS:
A breakthrough infection was defined as a positive test at least 14 days after a full vaccination regimen. Logistic regression was used to calculate aORs, which were adjusted for age, sex, and race information.RESULTS:
A total of 110,380 patients from the UC CORDS database were included. After adjustment, stage 5 CKD due to hypertension (aOR 7.33; 95% CI 4.86-10.69; p<.001; power=1) displayed higher odds of infection than any other comorbidity. Lung transplantation history (aOR 4.79; 95% CI 3.25-6.82; p<.001; power= 1), coronary atherosclerosis (aOR 2.12; 95% CI 1.77-2.52; p<.001; power=1), and vitamin D deficiency (aOR 1.87; 95% CI 1.69-2.06; p<.001; power=1) were significantly correlated to breakthrough infection. Patients with obesity in addition to essential hypertension (aOR 1.74; 95% CI 1.51-2.01; p<.001; power=1) and anemia (aOR 1.80; 95% CI 1.47-2.19; p<.001; power=1) were at additional risk of breakthrough infection compared to those with essential hypertension and anemia alone.CONCLUSIONS:
Further measures should be taken to prevent breakthrough infection for individuals with these conditions, such as acquiring additional doses of the SARS-CoV-2 vaccine to boost immunity.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19 Vaccines
/
COVID-19
Type of study:
Experimental Studies
/
Prognostic study
Topics:
Vaccines
Limits:
Humans
Language:
English
Journal:
Am J Med Sci
Year:
2023
Document Type:
Article
Affiliation country:
J.amjms.2023.04.019
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