GM Allotypes and COVID-19. A Pilot Study Performed on Sicilian Patients
Translational Medicine at Unisa
; 24(2), 2022.
Article
in English
| Web of Science | ID: covidwho-2309567
ABSTRACT
Several studies suggest that genetic variants that influence the onset, maintenance and resolution of the immune response might be fundamental in predicting the evolution of COVID-19. In the present paper, we analysed the dis-tribution of GM allotypes (the genetic markers of immunoglobulin g chains) in symptomatic and asymptomatic COVID-19 patients and in healthy controls, all born and residing in Sicily. Indeed, the role played by GM allotypes in immune responses and infection control is well known. Our findings show that the GM23 allotype is significantly reduced in healthy controls. Interestingly, in a previous study, Sicilians carrying the GM23 allotype were associated with the risk of developing a symptomatic Human Cytomegalovirus infection. However, a note of caution should be considered, due to the small sample size of patients and controls.
Full text:
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Collection:
Databases of international organizations
Database:
Web of Science
Language:
English
Journal:
Translational Medicine at Unisa
Year:
2022
Document Type:
Article
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