Factors associated with improved outcome of inhaled corticosteroid use in COVID-19: A single institutional study.
Medicine (Baltimore)
; 101(51): e32420, 2022 Dec 23.
Article
in English
| MEDLINE | ID: covidwho-2309751
ABSTRACT
Asthmatics seem less prone to adverse outcomes in coronavirus disease 2019 (COVID-19) and some data shows that inhaled corticosteroids (ICS) are protective. We gathered data on anecdotal ICS and outcomes of patients hospitalized with COVID-19, given there is literature supporting ICS may reduce risk of severe infection. In addition, we fill gaps in current literature evaluating Charlson Comorbidity Index (CCI) as a risk assessment tool for COVID-19. This was a single-center, retrospective study designed and conducted to identify factors associated intubation and inpatient mortality. A multivariate logistic regression model was fit to generate adjusted odds ratios (OR). Intubation was associated with male gender (OR, 2.815; 95% confidence interval [CI], 1.348-5.881; Pâ
=â
.006) and increasing body mass index (BMI) (OR, 1.053; 95% CI, 1.009-1.099; Pâ
=â
.019). Asthma was associated with lower odds for intubation (OR, 0.283; 95% CI, 0.108-0.74; Pâ
=â
.01). 80% of patients taking pre-hospital ICS were not intubated (nâ
=â
8). In-patient mortality was associated with male gender (OR, 2.44; 95% CI, 1.167-5.1; Pâ
=â
.018), older age (OR, 1.096; 95% CI, 1.052-1.142; P = <.001), and increasing BMI (OR, 1.079; 95% CI, 1.033-1.127; Pâ
=â
.001). Asthma was associated with lower in-patient mortality (OR, 0.221; 95% CI, 0.057-0.854; Pâ
=â
.029). CCI did not correlate with intubation (OR, 1.262; 95% CI, 0.923-1.724; Pâ
=â
.145) or inpatient mortality (OR, 0.896; 95% CI, 0.665-1.206; Pâ
=â
.468). Asthmatics hospitalized for COVID-19 had less adverse outcomes, and most patients taking pre-hospital ICS were not intubated. CCI score was not associated with intubation or inpatient mortality.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Asthma
/
Anti-Asthmatic Agents
/
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Humans
/
Male
Language:
English
Journal:
Medicine (Baltimore)
Year:
2022
Document Type:
Article
Affiliation country:
MD.0000000000032420
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