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SARS-CoV-2 induced coagulopathy and potential role of anticoagulation: Scoping review of literature.
Khakwani, Muhammad Mussab; Arshad, Ainan.
  • Zehra Naseem; Medical College, Aga Khan University, Karachi. zehranaseem11@gmail.com.
  • Khakwani MM; Medical College, Aga Khan University, Karachi. mussab_khak66@hotmail.com.
  • Maaha Ayub; Medical College, Aga Khan University, Karachi. maaha.ayub@gmail.com.
  • Ahmed Ayaz; Medical College, Aga Khan University, Karachi. ahmedayaz2019@gmail.com.
  • Bushra Jamil; Department of Medicine, Aga Khan University, Karachi. bushra.jamil@aku.edu.
  • Arshad A; Department of Medicine, Aga Khan University, Karachi. ainan_arshad@hotmail.com.
Monaldi Arch Chest Dis ; 92(4)2022 Jan 26.
Article in English | MEDLINE | ID: covidwho-2310092
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can vary on a spectrum of asymptomatic disease to rarer manifestations like hypercoagulability especially among elderly patients admitted in the intensive care unit (ICU) and those with preexisting comorbidities. The exact mechanism behind this phenomenon is still unclear, however studies have shown an association with elevated cytokines and severe inflammatory response which encompasses this disease. Hypercoagulability can be limited to the lungs, or present as systemic manifestations of arterial and venous thrombosis leading to mortal outcomes. Thus, careful evaluation of risk factors should be performed by physicians and treatment with anticoagulants should be modified accordingly. All Coronavirus Disease 2019 (COVID-19) in-patients should receive thromboprophylactic therapy, with increased dosages administered to patients with increased disease severity or those with a high risk. D-dimer levels and sepsis-induced coagulopathy (SIC) score aid in identifying high risk patients and predicting outcome. This article highlights the pathophysiology behind hypercoagulability, its clinical associations and discusses therapeutic modalities to combat this fatal consequence of SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Coagulation Disorders / Thrombophilia / COVID-19 Type of study: Experimental Studies / Prognostic study / Reviews Topics: Long Covid Limits: Aged / Humans Language: English Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Coagulation Disorders / Thrombophilia / COVID-19 Type of study: Experimental Studies / Prognostic study / Reviews Topics: Long Covid Limits: Aged / Humans Language: English Year: 2022 Document Type: Article