Recent progress of molecular diagnosis via CRISPR Cas-based biosensors and bioassays
Talanta Open
; 7:100225, 2023.
Article
in English
| ScienceDirect | ID: covidwho-2310110
ABSTRACT
The immune systems of bacteria and archaea served as the inspiration for CRISPR/Cas technology, which won the 2020 Nobel Prize in Chemistry for its achievements in genetic manipulation. Because of its enormous value globally, molecular diagnostics emerged as a fresh wave of diagnostic technologies. A growing number of studies have demonstrated the compatibility of CRISPR/Cas technology with biosensors and bioassays for molecular diagnostics. As highly precise, sensitive, easily programmable, and device-independent sensors, CRISPR-based detection has received a lot of interest. One of the most precise and sensitive diagnostic techniques is nucleic acid-based detection. It has the potential for detecting other biomarkers, such as proteins and tiny compounds, with more study. This study provides insight into CRISPR-based biosensors and recent advancements from nucleic acids to other non-nucleic small molecules or analytes such as proteins and presents the challenges and perspectives of CRISPR biosensors and bioassays.
Full text:
Available
Collection:
Databases of international organizations
Database:
ScienceDirect
Language:
English
Journal:
Talanta Open
Year:
2023
Document Type:
Article
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