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Association between hypersomnolence and the COVID-19 pandemic: The International COVID-19 Sleep Study (ICOSS).
Sarkanen, Tomi; Partinen, Markku; Bjorvatn, Bjørn; Merikanto, Ilona; Benedict, Christian; Nadorff, Michael R; Bolstad, Courtney J; Espie, Colin; Matsui, Kentaro; Chung, Frances; Morin, Charles M; Wing, Yun Kwok; Penzel, Thomas; Macêdo, Tainá; Mota-Rolim, Sérgio; Holzinger, Brigitte; Plazzi, Giuseppe; De Gennaro, Luigi; Landtblom, Anne-Marie; Inoue, Yuichi; Sieminski, Mariuz; Leger, Damien; Dauvilliers, Yves.
  • Sarkanen T; Department of Neurology, Tampere University Hospital, Tampere, Finland; Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland. Electronic address: Tomi.sarkanen@pirha.fi.
  • Partinen M; Department of Clinical Neurosciences, Clinicum, University of Helsinki, Helsinki, Finland; Helsinki Sleep Clinic, Terveystalo Healthcare, Helsinki, Finland. Electronic address: markku.partinen@helsinki.fi.
  • Bjorvatn B; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Norwegian Competence Center for Sleep Disorders, Haukeland University Hospital, Bergen, Norway.
  • Merikanto I; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland; Orton Orthopaedics Hospital, Helsinki, Finland.
  • Benedict C; Department of Pharmaceutical Biosciences, Molecular Neuropharmacology, Uppsala University, Uppsala, Sweden.
  • Nadorff MR; Department of Psychology, Mississippi State University, Mississippi State, MS, 39762, USA; Sir Jules Thorn Sleep & Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, UK.
  • Bolstad CJ; Department of Psychology, Mississippi State University, Mississippi State, MS, 39762, USA.
  • Espie C; Sir Jules Thorn Sleep & Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, UK.
  • Matsui K; Department of Clinical Laboratory, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
  • Chung F; Department of Anesthesiology and Pain Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Morin CM; Université Laval, Quebec City, Canada.
  • Wing YK; Li Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
  • Penzel T; Sleep Medicine Center, Charite University Hospital, Berlin, Germany.
  • Macêdo T; Department of Psychology, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Mota-Rolim S; Brain Institute, Physiology and Behavior Department, Onofre Lopes University Hospital - Federal University of Rio Grande do Norte, Natal, Brazil.
  • Holzinger B; MasterULG Schlafcoaching, Medical University Vienna, Austria.
  • Plazzi G; IRCCS-Istituto delle Scienze Neurologiche Di Bologna, Bologna, Italy; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • De Gennaro L; Department of Psychology, Sapienza University of Rome, Roma, Lazio, Italy; IRCCS Fondazione Santa Lucia, Roma, Italy.
  • Landtblom AM; Dept of Medical Sciences, Uppsala university, Uppsala, Sweden.
  • Inoue Y; Department of Somnology, Tokyo Medical University, Tokyo, Japan.
  • Sieminski M; Department of Emergency Medicine, Medical University of Gdansk, Poland.
  • Leger D; VIFASOM, Université Paris Cité et APHP Hôtel Dieu, Centre du Sommeil et de la Vigilance, Paris, France.
  • Dauvilliers Y; Sleep-Wake Disorders Center, Department of Neurology, Gui-de-Chauliac Hospital, Institute for Neurosciences of Montpellier INM, INSERM, University of Montpellier, Montpellier, France. Electronic address: y-dauvilliers@chu-montpellier.fr.
Sleep Med ; 107: 108-115, 2023 07.
Article in English | MEDLINE | ID: covidwho-2310814
ABSTRACT

BACKGROUND:

The COVID-19 pandemic and related restriction measures have affected our daily life, sleep, and circadian rhythms worldwide. Their effects on hypersomnolence and fatigue remain unclear.

METHODS:

The International COVID-19 Sleep Study questionnaire which included items on hypersomnolence such as excessive daytime sleepiness (EDS), and excessive quantity of sleep (EQS), as well as sociodemographic factors, sleep patterns, psychological symptoms, and quality of life was distributed in 15 countries across the world from May to September in 2020.

RESULTS:

Altogether responses from 18,785 survey participants (65% women, median age 39 years) were available for analysis. Only 2.8% reported having had COVID-19. Compared to before the pandemic, the prevalence of EDS, EQS, and fatigue increased from 17.9% to 25.5%, 1.6%-4.9%, and 19.4%-28.3% amid the pandemic, respectively. In univariate logistic regression models, reports of having a COVID-19 were associated with EQS (OR 5.3; 95%-CI 3.6-8.0), EDS (2.6; 2.0-3.4), and fatigue (2.8; 2.1-3.6). In adjusted multivariate logistic regression, sleep duration shorter than desired (3.9; 3.2-4.7), depressive symptoms (3.1; 2.7-3.5), use of hypnotics (2.3; 1.9-2.8), and having reported COVID-19 (1.9; 1.3-2.6) remained strong predictors of EDS. Similar associations emerged for fatigue. In the multivariate model, depressive symptoms (4.1; 3.6-4.6) and reports of having COVID-19 (2.0; 1.4-2.8) remained associated with EQS.

CONCLUSIONS:

A large increase in EDS, EQS, and fatigue occurred due to the COVID-19 pandemic, and especially in self-reported cases of COVID-19. These findings warrant a thorough understanding of their pathophysiology to target prevention and treatment strategies for long COVID condition.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Disorders of Excessive Somnolence Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male Language: English Journal: Sleep Med Journal subject: Neurology / Psychophysiology Year: 2023 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Disorders of Excessive Somnolence Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male Language: English Journal: Sleep Med Journal subject: Neurology / Psychophysiology Year: 2023 Document Type: Article