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Conductive Thread-Based Immunosensor for Pandemic Influenza A (H1N1) Virus Detection.
Son, Seong Uk; Jang, Soojin; Lim, Jaewoo; Seo, Seung Beom; Kang, Taejoon; Jung, Juyeon; Oh, Seo Yeong; Yoon, Sun-Woo; Yong, Dongeun; Lee, Jaejong; Lim, Eun-Kyung.
  • Son SU; Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.
  • Jang S; Department of Nanobiotechnology, KRIBB School of Biotechnology, University of Science and Technology (UST), Daejeon 34113, Republic of Korea.
  • Lim J; Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.
  • Seo SB; Department of Nanobiotechnology, KRIBB School of Biotechnology, University of Science and Technology (UST), Daejeon 34113, Republic of Korea.
  • Kang T; Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.
  • Jung J; Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.
  • Oh SY; Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 46241, Republic of Korea.
  • Yoon SW; Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.
  • Yong D; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • Lee J; Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.
  • Lim EK; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
ACS Appl Mater Interfaces ; 15(6): 7759-7766, 2023 Feb 15.
Article in English | MEDLINE | ID: covidwho-2311054
ABSTRACT
Infectious agents such as viruses pose significant threats to human health, being transmitted via direct contact as well as airborne transmission without direct contact, thus requiring rapid detection to prevent the spread of infectious diseases. In this study, we developed a conductive thread-based immunosensor (CT-IS), a biosensor to easily detect the presence of airborne viruses. CT-IS utilizes an antibody that specifically recognizes the HA protein of the pandemic influenza A (pH1N1) virus, which is incorporated into the conductive thread. The antigen-antibody interaction results in increased strain on the conductive thread in the presence of the pH1N1 virus, resulting in increased electrical resistance of the CT-IS. We evaluated the performance of this sensor using the HA protein and the pH1N1 virus, in addition to samples from patients infected with the pH1N1 virus. We observed a significant change in resistance in the pH1N1-infected patient samples (positive n = 11, negative n = 9), whereas negligible change was observed in the control samples (patients not infected with the pH1N1 virus; negative). Hence, the CT-IS is a lightweight fiber-type sensor that can be used as a wearable biosensor by combining it with textiles, to detect the pH1N1 virus in a person's vicinity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Biosensing Techniques / Influenza, Human / Influenza A Virus, H1N1 Subtype Type of study: Diagnostic study / Experimental Studies Limits: Humans Language: English Journal: ACS Appl Mater Interfaces Journal subject: Biotechnology / Biomedical Engineering Year: 2023 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Biosensing Techniques / Influenza, Human / Influenza A Virus, H1N1 Subtype Type of study: Diagnostic study / Experimental Studies Limits: Humans Language: English Journal: ACS Appl Mater Interfaces Journal subject: Biotechnology / Biomedical Engineering Year: 2023 Document Type: Article