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Hydrogen sulfide: physiological roles and therapeutic implications against COVID-19.
Abolfazli, Sajad; Ebrahimi, Nima; Morabi, Eftekhar; Asgari Yazdi, Mohammad Amin; Zengin, Gokhan; Sathyapalan, Thozhukat; Jamialahmadi, Tannaz; Sahebkar, Amirhossein.
  • Abolfazli S; Student Research Committee, School of Pharmacy, Mazandaran University of Medical Science, Sari, Iran.
  • Ebrahimi N; Student Research Committee, School of Pharmacy, Mashhad University of Medical Science, Mashhad, Iran.
  • Morabi E; Student Research Committee, School of Pharmacy, Shahid Sadoughi University of Medical Science, Yazd, Iran.
  • Asgari Yazdi MA; Mashhad University of Medical Sciences Student Research Committee Mashhad Iran.
  • Zengin G; Department of Biology, Science Faculty, Selcuk University, Konya 42130, Turkey.
  • Sathyapalan T; Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, United Kingdom of Great Britain and Northern Ireland.
  • Jamialahmadi T; Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Sahebkar A; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Curr Med Chem ; 2023 May 02.
Article in English | MEDLINE | ID: covidwho-2312146
ABSTRACT
The COVID-19 pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) poses a major menace to economic and public health worldwide. Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) are two host proteins that play an essential function in the entry of SARS-COV-2 into host cells. Hydrogen sulfide (H2S), a new gasotransmitter, has been shown to protect the lungs from potential damage through its anti-inflammatory, antioxidant, antiviral, and anti-aging effects. It is well known that H2S is crucial in controlling the inflammatory reaction and the pro-inflammatory cytokine storm. Therefore, it has been suggested that some H2S donors may help treat acute lung inflammation. Furthermore, recent research illuminates a number of mechanisms of action that may explain the antiviral properties of H2S. Some early clinical findings indicate a negative correlation between endogenous H2S concentrations and COVID-19 intensity. Therefore, reusing H2S-releasing drugs could represent a curative option for COVID-19 therapy.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal subject: Chemistry Year: 2023 Document Type: Article Affiliation country: 0929867330666230502111227

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal subject: Chemistry Year: 2023 Document Type: Article Affiliation country: 0929867330666230502111227