Immunological fingerprint in coronavirus disease-19 convalescents with and without post-COVID syndrome.
Front Med (Lausanne)
; 10: 1129288, 2023.
Article
in English
| MEDLINE | ID: covidwho-2312721
ABSTRACT
Background:
Symptoms lasting longer than 12 weeks after severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection are called post-coronavirus disease (COVID) syndrome (PCS). The identification of new biomarkers that predict the occurrence or course of PCS in terms of a post-viral syndrome is vital. T-cell dysfunction, cytokine imbalance, and impaired autoimmunity have been reported in PCS. Nevertheless, there is still a lack of conclusive information on the underlying mechanisms due to, among other things, a lack of controlled study designs.Methods:
Here, we conducted a prospective, controlled study to characterize the humoral and cellular immune response in unvaccinated patients with and without PCS following SARS-CoV-2 infection over 7â¯months and unexposed donors.Results:
Patients with PCS showed as early as 6â¯weeks and 7â¯months after symptom onset significantly increased frequencies of SARS-CoV-2-specific CD4+ and CD8+ T-cells secreting IFNγ, TNF, and expressing CD40L, as well as plasmacytoid dendritic cells (pDC) with an activated phenotype. Remarkably, the immunosuppressive counterparts type 1 regulatory T-cells (TR1 CD49b/LAG-3+) and IL-4 were more abundant in PCS+.Conclusion:
This work describes immunological alterations between inflammation and immunosuppression in COVID-19 convalescents with and without PCS, which may provide potential directions for future epidemiological investigations and targeted treatments.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Long Covid
Language:
English
Journal:
Front Med (Lausanne)
Year:
2023
Document Type:
Article
Affiliation country:
Fmed.2023.1129288
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