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Unique properties of tissue-resident memory T cells in the lungs: implications for COVID-19 and other respiratory diseases.
Carbone, Francis R.
  • Carbone FR; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. fcarbone@unimelb.edu.au.
Nat Rev Immunol ; 23(5): 329-335, 2023 05.
Article in English | MEDLINE | ID: covidwho-2313397
ABSTRACT
Tissue-resident memory T (TRM) cells were originally identified as a tissue-sequestered population of memory T cells that show lifelong persistence in non-lymphoid organs. That definition has slowly evolved with the documentation of TRM cells having variable terms of tissue residency combined with a capacity to return to the wider circulation. Nonetheless, reductionist experiments have identified an archetypical population of TRM cells showing intrinsic permanent residency in a wide range of non-lymphoid organs, with one notable exception the lungs. Despite the fact that memory T cells generated during a respiratory infection are maintained in the circulation, local TRM cell numbers in the lung decline concomitantly with a decay in T cell-mediated protection. This Perspective describes the mechanisms that underpin long-term T cell lodgement in non-lymphoid tissues and explains why residency is transient for select TRM cell subsets. In doing so, it highlights the unusual nature of memory T cell egress from the lungs and speculates on the broader disease implications of this process, especially during infection with SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Nat Rev Immunol Journal subject: Allergy and Immunology Year: 2023 Document Type: Article Affiliation country: S41577-022-00815-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Nat Rev Immunol Journal subject: Allergy and Immunology Year: 2023 Document Type: Article Affiliation country: S41577-022-00815-z