Sirna-A Potential Therapy for Covid-19 Infection
International Journal of Pharmaceutical Research
; 15(1):145-149, 2023.
Article
in English
| EMBASE | ID: covidwho-2314038
ABSTRACT
Background:
The deadly virus COVID-19 has affected more than 1 crore people and claimed more than 5 lakh lives worldwide according to the World health organization. Though there are numerous treatment modalities available including anti-bacterials, antivirals, vaccines etc., none of them can be considered as effective cure for SARS CoV-2 virus as they are mostly non-specific in action. Aim(s) siRNA therapy can be considered as a significant treatment modality due to its specificity in action. The aim of this review is to explore siRNA as a potential treatment strategy for the treatment of COVID-19. Material(s) and Method(s) In this review we shall explore the targets of siRNA therapy which includes viral RNA-dependent RNA polymerase, helicase, protease and nucleoprotein N. siRNA related patents provide solutions for novel RNAi techniques, high expense of chemically synthetic siRNA, techniques for restraining SARS-CoV by disturbing RNA etc., siRNA-based drug delivery systems and limitations of nanocarrier delivery system were reviewed. siRNA is a gene silencer that targets highly conserved sequences which codes for protease 3CL (nsp5) and viral helicase (from 16-18 kbp). Conclusion(s) Thus, siRNA-based therapy is considered highly efficacious as it can hit the highly conserved regions of SARS-CoV-2 RNA.Copyright © 2023, Advanced Scientific Research. All rights reserved.
covid-19; gene silencer; nanocarrier drug delivery system; Protease; siRNA therapy; Viral helicase; biosynthesis; conserved sequence; coronavirus disease 2019/dt [Drug Therapy]; drug delivery system; drug specificity; gene control; gene expression; gene silencing; human; maturation; review; Severe acute respiratory syndrome coronavirus 2; virus attachment; virus entry; virus pathogenesis; virus release; helicase; nanocarrier; nucleoprotein; proteinase; RNA directed RNA polymerase; RNA polymerase; small interfering RNA/dt [Drug Therapy]
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
International Journal of Pharmaceutical Research
Year:
2023
Document Type:
Article
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