Multiple Cerebral Infarcts Triggered by Sars-Cov-2 Virus in an Asymptomatic Cadasil Patient: Case Report
Turk Beyin Damar Hastaliklar Dergisi
; 29(1):50-53, 2023.
Article
in English
| EMBASE | ID: covidwho-2314165
ABSTRACT
During the coronavirus pandemic, increasing evidence has confirmed that the SARS-CoV-2 virus is susceptible to increased risk of stroke. On the other hand, the relationship between the SARS-CoV-2 virus and CADASIL was among the topics discussed in the literature with a small number of cases. In this case report, we present multiple cerebral infarcts in an asymptomatic CADASIL patient and we aim to shed light on the complex nature of cerebrovascular manifestations of the SARS-CoV-2 virus. A 50-year-old man with an unremarkable past medical history was admitted to our department with fever and neurologic manifestations on the 6th day of self-isolation due to positive reverse-transcriptase-polymerasechain-reaction assay in a nasopharyngeal sample for SARS-CoV-2. Neurological deficits were related to the acute vascular lesions located in the border-zone areas of both hemispheres, corpus callosum, and cerebellar peduncles on brain MRI. Lesions in chronic nature in the bilateral subcortical white matter predominantly involving the external capsule and temporal poles were also challenging. As a result of a comprehensive study that could explain the neurological status and imaging findings, the CADASIL diagnosis is reached by genetic testing for NOTCH-3. The experience, in this case, suggests considering patients with suspicious MRI findings for CADASIL diagnosis during the coronavirus pandemic. Further studies are needed to explain the underlying pathophysiological mechanisms related to cerebrovascular manifestations of SARS-CoV-2.Copyright © 2022 by Turkish Cerebrovascular Diseases Society.
cadasil; notch-3; SARS-CoV-2; stroke; adult; article; brain infarction; case report; cerebellar peduncle; cerebrovascular accident; clinical article; corpus callosum; external capsule; fever; flower stalk; genetic screening; home quarantine; human; male; medical history; middle aged; neuroimaging; neurologic disease; nonhuman; nuclear magnetic resonance imaging; pandemic; Severe acute respiratory syndrome coronavirus 2; vascular lesion; white matter; endogenous compound; Notch3 receptor; RNA directed DNA polymerase
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Case report
Language:
English
Journal:
Turk Beyin Damar Hastaliklar Dergisi
Year:
2023
Document Type:
Article
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