Maternal and Perinatal Outcomes of SARS-CoV-2 and Variants in Pregnancy
Maternal-Fetal Medicine
; 5(2):104-114, 2023.
Article
in English
| EMBASE | ID: covidwho-2314478
ABSTRACT
Pregnancy is a physiological state that predisposes women to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, a disease that can cause adverse maternal and perinatal outcomes. The severity of coronavirus disease 2019 (COVID-19) disease is known to vary by viral strain;however, evidence for the effects of this virus in pregnant women has yet to be fully elucidated. In this review, we describe maternal and perinatal outcomes, vaccination, and vertical transmission, among pregnant women infected with the different SARS-CoV-2 variants identified to date. We also summarize existing evidence for maternal and perinatal outcomes in pregnant women with specific information relating to SARS-CoV-2 variants. Our analysis showed that Omicron infection was associated with fewer severe maternal and perinatal adverse outcomes while the Delta variant was associated with worse pregnancy outcomes. Maternal deaths arising from COVID-19 were found to be rare (<1.0%), irrespective of whether the virus was a wild-Type strain or a variant. Severe maternal morbidity was more frequent for the Delta variant (10.3%), followed by the Alpha (4.7%), wild-Type (4.5%), and Omicron (2.9%) variants. The rates of stillbirth were 0.8%, 4.1%, 3.1%, and 2.3%, respectively, in pregnancies infected with the wild-Type strain, Alpha, Delta, and Omicron variants, respectively. Preterm birth and admission to neonatal intensive care units were more common for cases with the Delta infection (19.0% and 18.62%, respectively), while risks were similar for those infected with the wild-Type (14.7% and 11.2%, respectively), Alpha (14.9% and 13.1%), and Omicron variants (13.2% and 13.8%, respectively). As COVID-19 remains a global pandemic, and new SARS-CoV-2 variants continue to emerge, research relating to the specific impact of new variants on pregnant women needs to be expanded.Copyright © Wolters Kluwer Health, Inc. All rights reserved.
Alpha; covid-19; Delta; Omicron; Pregnancy outcomes; SARS-CoV-2; Variants; adult; adverse outcome; controlled study; coronavirus disease 2019; female; hepatitis D; human; maternal death; maternal morbidity; neonatal intensive care unit; nonhuman; outcome assessment; pandemic; pregnancy; pregnancy outcome; pregnant woman; prematurity; review; Severe acute respiratory syndrome coronavirus 2; stillbirth; vaccination; vertical transmission; wild type
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Topics:
Variants
Language:
English
Journal:
Maternal-Fetal Medicine
Year:
2023
Document Type:
Article
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