Transgender Women Baseline Profile in Transcitar: Transspecific Cohort in Argentina
Topics in Antiviral Medicine
; 31(2):343-344, 2023.
Article
in English
| EMBASE | ID: covidwho-2314641
ABSTRACT
Background:
Transgender women (TGW) are among the population most affected by the HIV epidemic in Argentina, despite a progressive legal framework. TransCITAR is a trans-specific cohort in Argentina that aims to assess physical and mental health among transgender and non-binary people (TGNBP). We present baseline characteristics of TGW. Method(s) TGW attending a trans-friendly clinic to receive HIV/STIs prevention/ treatment, mental health care and/or gender-affirming hormone therapy (GHT) were invited to participate. Semiannual visits including clinical assessments, laboratory tests, and psychosocial interviews were performed. Oral PrEP was offered as part of a combined prevention strategy since September 2021. Result(s) Between September/2019 and August/2022, 500 TGNBP were enrolled, 416 were TGW (median age 30 years, IQR 25-37). High social vulnerability was observed (Table 1). Regarding trans-specific characteristics, 49.8% reported industrial silicone injections and 36.8% were receiving GHT. 76.9% were sex workers. Baseline STIs prevalence were HIV 42.3% (10.2% diagnosed at enrolment), syphilis 40% (defined as positive nontreponemal test VDRL with titers of at least 1/8), past HBV 18.5%, chronic HBV 3.8%, HCV antibody positive 2.6%. Only 57% presented HBV protective antibodies titers (HBVsAb>=10UI/ml), 8 TGW were on PreP. For those with HIV, median CD4+ cell count was 602 cells/mm3 (IQR 378-933), 66.5% were on ART at enrolment (53.6% were virally suppressed) and 14.8% initiated at baseline. During 36 months of follow up, 4 TGW died (one AIDS-related and one COVID-19-related). Bivariate analyses showed that a positive HIV diagnosis was independently associated with migration, low level of education, unstable housing, silicone injecion and sex work, while was negatively associated with being on GHT. In multivariable logistic regression, only sociodemographic variables remain associated migrant (aOR=.487, 95% CI=.304-.768);incomplete high school (aOR=.463, 95% CI=.300=.714);unstable housing (aOR=.614, 95% CI=.401- .940);and sex work (aOR=.324, 95% CI=.177-.593). Conclusion(s) TGW from TransCITAR presented poor healthoutcomes:
high prevalence of HIV/syphilis, high proportion with incomplete/no HBV vaccine and high levels of depression and violence. A comprehensive approach to care and addressing social determinants of health is pivotal to reduce HIV burden in this population.
acquired immune deficiency syndrome; adult; Argentina; bivariate analysis; cell count; clinical assessment; conference abstract; controlled study; coronavirus disease 2019; depression; education; educational status; female; follow up; Hepatitis C virus; high school; hormonal therapy; housing; human; human cell; Human immunodeficiency virus; interview; laboratory test; major clinical study; male; mental health care; migrant; nonhuman; outcome assessment; pre-exposure prophylaxis; prevalence; prevention; sex worker; social determinants of health; social vulnerability; sociodemographics; syphilis; transgender; transgender and gender nonbinary; violence; CD4 antigen; endogenous compound; silicone; vaccine
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Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Country/Region as subject:
South America
/
Argentina
Language:
English
Journal:
Topics in Antiviral Medicine
Year:
2023
Document Type:
Article
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