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Spectrum of Serious Neurological and Psychiatric Adverse Events in Indian COVID-19 Vaccine Recipients: A Systematic Review of Case Reports and Case Series.
Garg, Ravindra Kumar; Paliwal, Vimal; Malhotra, Hardeep Singh; Singh, Balendra Pratap; Rizvi, Imran; Kumar, Neeraj.
  • Garg RK; Department of Neurology, King George's Medical University, Lucknow, UP, India.
  • Paliwal V; Department of Neurology, Sanjay Gandhi Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
  • Malhotra HS; Department of Neurology, King George's Medical University, Lucknow, UP, India.
  • Singh BP; Department of Prosthodontics, King George's Medical University, Lucknow, UP, India.
  • Rizvi I; Department of Neurology, King George's Medical University, Lucknow, UP, India.
  • Kumar N; Department of Neurology, King George's Medical University, Lucknow, UP, India.
Neurol India ; 71(2): 209-227, 2023.
Article in English | MEDLINE | ID: covidwho-2314756
ABSTRACT
Indian data regarding serious neurological and psychiatric adverse events, following coronavirus disease 2019 (COVID-19) vaccination, are lacking. We, therefore, systematically evaluated cases of post-vaccinal serious neurological and psychiatric adverse reactions published from India. A systematic review of cases published from India, which were archived in PubMed, Scopus, and Google Scholar databases, was performed; pre-print databases along with ahead-of-print contents were searched in addition. Retrieved articles, as on June 27, 2022, were evaluated following PRISMA guidelines. EndNote 20 web tool was used to make a PRISMA flow chart. Individual patients' data were compiled in a tabular form. The protocol of the systematic review was registered with PROSPERO (CRD42022324183). A total of 64 records describing 136 instances of serious neurological and psychiatric adverse events were identified. More than 50% (36/64) reports were from the following four states, namely, Kerala, Uttar Pradesh, New Delhi, and West Bengal. The mean age of persons developing these complications was 44.89 ± 15.77 years. In the majority, adverse events occurred within 2 weeks of administration of the first dose of COVISHIELD vaccine. Immune-mediated central nervous system (CNS) disorders were identified in 54 instances. Guillain-Barre syndrome and other immune-mediated peripheral neuropathies were reported in 21 cases. Post-vaccinal herpes zoster was recorded in 31 vaccine recipients. Psychiatric adverse events were recorded in six patients. In Indian recipients of COVID-19 vaccine, a variety of serious neurological complications were reported. The overall risk appears minuscule. Immune-mediated central and peripheral neuronal demyelinations were the most frequently reported post-vaccinal adverse events. A large number of cases of herpes zoster have also been reported. Immune-mediated disorders responded well to immunotherapy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / Peripheral Nervous System Diseases / Guillain-Barre Syndrome / COVID-19 / Herpes Zoster Type of study: Case report / Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Long Covid / Vaccines Limits: Adult / Humans / Middle aged Language: English Journal: Neurol India Year: 2023 Document Type: Article Affiliation country: 0028-3886.375420

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / Peripheral Nervous System Diseases / Guillain-Barre Syndrome / COVID-19 / Herpes Zoster Type of study: Case report / Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Long Covid / Vaccines Limits: Adult / Humans / Middle aged Language: English Journal: Neurol India Year: 2023 Document Type: Article Affiliation country: 0028-3886.375420