Covid-19 Vaccine Coverage among People with Hiv in the Vaccine Safety Datalink
Topics in Antiviral Medicine
; 31(2):406-407, 2023.
Article
in English
| EMBASE | ID: covidwho-2315279
ABSTRACT
Background:
People with HIV (PWH) may be at increased risk for severe COVID-19 outcomes compared with people without HIV. However, COVID-19 vaccination coverage among PWH is largely unknown, especially among those with advanced HIV or comorbidities. Method(s) We conducted a cohort study to evaluate coverage of the initial COVID-19 vaccine primary series and factors associated with the completion in adult PWH (>=18 years) enrolled in 8 healthcare organizations participating in the Vaccine Safety Datalink (VSD) project during December 1, 2020- December 31, 2021. Completion of two doses of the Pfizer-BioNTech or Moderna mRNA COVID-19 vaccines or one dose of the single-dose Janssen COVID-19 vaccine was assessed. Multivariable analysis was conducted using a robust Poisson regression model to estimate the rate ratio (RR) for factors associated with primary series completion, accounting for follow-up time. Result(s) A total of 22,063 PWH were identified, among which 89% were male and 93% were viral suppressed (viral load, VL <=200 copies/ml). Chronic comorbid conditions were prevalent, with 25% having a Charlson comorbidity score of 1-2 and 13% having a score of 3 or greater. About 23% were overweight and 17% were obese. The majority (90%) completed the primary series and 1,782 PWH (8%) did not receive any dose during the study period. A rapid uptake was achieved within the 6 months after the national COVID-19 vaccination program launched on December 14, 2020. (Figure 1) PWH who received one dose of mRNA vaccine (i.e., partially vaccinated) were excluded (n=314) from the analysis for the primary series completion. Having received an influenza vaccination in the past 2 years was the strongest predictor of completion (RR=1.17, 95%CI 1.15, 1.20). Males (RR= 1.06, 95%CI 1.04-1.08) and those of Asian race (RR=1.05, 95%CI 1.03-1.06, vs. White) were more likely to complete the primary series. However, PWH with baseline CD4 counts < 200 (RR=0.97, 95%CI 0.94-0.99) and those failing to achieve viral suppression (VL= 201-10k RR= 0.89, 95%CI 0.85-0.94;VL >10k RR= 0.92, 95%CI 0.87-0.98) were less likely to complete the primary series. Body mass index, Charlson comorbidity score, and neighborhood household income level were not associated with completion. Conclusion(s) Coverage of the COVID-19 vaccine primary series was high in adult PWH in the VSD. However, targeted vaccination outreach is warranted for PWH with low CD4 counts and uncontrolled HIV viral load.
adult; body mass; Caucasian; CD4 lymphocyte count; Charlson Comorbidity Index; cohort analysis; conference abstract; controlled study; coronavirus disease 2019; drug safety; female; follow up; health care organization; household income; human; Human immunodeficiency virus; influenza vaccination; major clinical study; male; neighborhood; nonhuman; obesity; Poisson regression; vaccination; virus load; ibacovavec; RNA vaccine
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Collection:
Databases of international organizations
Database:
EMBASE
Topics:
Vaccines
Language:
English
Journal:
Topics in Antiviral Medicine
Year:
2023
Document Type:
Article
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