Alzheimer's disease and COVID-19.
Nevrologiya, Neiropsikhiatriya, Psikhosomatika
; 14(6):89-97, 2022.
Article
in Russian
| EMBASE | ID: covidwho-2316157
ABSTRACT
In elderly patients with COVID-19 cognitive functions decline;it has been suggested that SARS-CoV-2 infection may lead to the development of Alzheimer's disease (AD) and other long-term neurological consequences. We review several parallels between AD and COVID-19 in terms of pathogenetic mechanisms and risk factors. Possible mechanisms through which COVID-19 can initiate AD are discussed. These include systemic inflammation, hyperactivation of the renin-angiotensin system, innate immune activation, oxidative stress, and direct viral damage. It has been shown that increased expression of angiotensin-renin receptors (ACE2) may be a risk factor for COVID-19 in patients with AD. When entering the central nervous system, the SARS-CoV-2 virus can directly activate glial cell-mediated immune responses, which in turn can lead to the accumulation of beta-amyloid and the subsequent onset or progression of current AD. The involvement of inflammatory biomarkers, including interleukins (IL) IL6, IL1, as well as galectin-3, as a link between COVID-19 and AD is discussed. The rationale for the use of memantine (akatinol memantine) in patients with COVID-19 in order to prevent the development of cognitive deficits is discussed. Memantine has been shown to have a positive effect on neuroinflammatory processes in the onset or exacerbation of cognitive deficits, in reducing cerebral vasospasm and endothelial dysfunction in viral infections. Memantine therapy may improve everyday activity and reduce the risk of severe SARS-CoV-2 infection.Copyright © 2022 Ima-Press Publishing House. All rights reserved.
akatinol memantine; Alzheimer's disease; cognitive impairment; coronavirus infection; covid-19; memantine; SARS-CoV-2 infection; aged; Alzheimer disease; brain vasospasm; cellular immunity; central nervous system; cognition; cognitive defect; coronavirus disease 2019; disease exacerbation; drug therapy; endothelial dysfunction; gene expression; glia cell; human; immunostimulation; inflammation; nonhuman; oxidative stress; prevention; protein expression; renin angiotensin aldosterone system; review; risk factor; Severe acute respiratory syndrome coronavirus 2; amyloid beta protein; angiotensin; angiotensin converting enzyme 2; biological marker; endogenous compound; galectin 3; interleukin 6; interleukin derivative; renin
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
Russian
Journal:
Nevrologiya, Neiropsikhiatriya, Psikhosomatika
Year:
2022
Document Type:
Article
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