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The Role of Histone Deacetylases in Acute Lung Injury-Friend or Foe.
Luo, Guoqing; Liu, Bohao; Fu, Tinglv; Liu, Yi; Li, Boyang; Li, Ning; Geng, Qing.
  • Luo G; Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
  • Liu B; Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
  • Fu T; Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
  • Liu Y; Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
  • Li B; Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
  • Li N; Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
  • Geng Q; Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Int J Mol Sci ; 24(9)2023 Apr 26.
Article in English | MEDLINE | ID: covidwho-2316764
ABSTRACT
Acute lung injury (ALI), caused by intrapulmonary or extrapulmonary factors such as pneumonia, shock, and sepsis, eventually disrupts the alveolar-capillary barrier, resulting in diffuse pulmonary oedema and microatasis, manifested by refractory hypoxemia, and respiratory distress. Not only is ALI highly lethal, but even if a patient survives, there are also multiple sequelae. Currently, there is no better treatment than supportive care, and we urgently need to find new targets to improve ALI. Histone deacetylases (HDACs) are epigenetically important enzymes that, together with histone acetylases (HATs), regulate the acetylation levels of histones and non-histones. While HDAC inhibitors (HDACis) play a therapeutic role in cancer, inflammatory, and neurodegenerative diseases, there is also a large body of evidence suggesting the potential of HDACs as therapeutic targets in ALI. This review explores the unique mechanisms of HDACs in different cell types of ALI, including macrophages, pulmonary vascular endothelial cells (VECs), alveolar epithelial cells (AECs), and neutrophils.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endothelial Cells / Acute Lung Injury Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Year: 2023 Document Type: Article Affiliation country: Ijms24097876

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endothelial Cells / Acute Lung Injury Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Year: 2023 Document Type: Article Affiliation country: Ijms24097876