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Establishment of reference intervals for complete blood count in times of COVID-19 and vaccination.
Mendieta-Gutiérrez, Claudia; Chávez-González, Selene; Rodríguez-Romero, Brenda Ivonne; Sánchez-Garrido, Jazmín Anahí; Figueroa-Gómez, Arturo; Licona-Vela, Jesús Bernabé; Juárez-Pérez, Arturo Cuauhtémoc; Cabello-López, Alejandro; Aguilar-Madrid, Guadalupe; Jiménez-Ramírez, Carmina.
  • Mendieta-Gutiérrez C; Clinical Analysis Laboratory, Traumatology Hospital "Dr. Victorio de la Fuente Narváez", High Specialty Medical Unit, Mexican Social Security Institute (IMSS), Mexico City, México.
  • Chávez-González S; Clinical Analysis Laboratory, Regional Zone Hospital No.24, IMSS, Mexico City, México.
  • Rodríguez-Romero BI; Clinical Analysis Laboratory, Traumatology Hospital "Dr. Victorio de la Fuente Narváez", High Specialty Medical Unit, Mexican Social Security Institute (IMSS), Mexico City, México.
  • Sánchez-Garrido JA; Clinical Analysis Laboratory, Traumatology Hospital "Dr. Victorio de la Fuente Narváez", High Specialty Medical Unit, Mexican Social Security Institute (IMSS), Mexico City, México.
  • Figueroa-Gómez A; Clinical Analysis Laboratory, Traumatology Hospital "Dr. Victorio de la Fuente Narváez", High Specialty Medical Unit, Mexican Social Security Institute (IMSS), Mexico City, México.
  • Licona-Vela JB; Clinical Analysis Laboratory, Traumatology Hospital "Dr. Victorio de la Fuente Narváez", High Specialty Medical Unit, Mexican Social Security Institute (IMSS), Mexico City, México.
  • Juárez-Pérez AC; Occupational Health Research Unit, National Medical Center "Siglo XXI", IMSS, Mexico City, México.
  • Cabello-López A; Occupational Health Research Unit, National Medical Center "Siglo XXI", IMSS, Mexico City, México.
  • Aguilar-Madrid G; Department of Public Health, Faculty of Medicine, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico.
  • Jiménez-Ramírez C; Clinical Analysis Laboratory, Traumatology Hospital "Dr. Victorio de la Fuente Narváez", High Specialty Medical Unit, Mexican Social Security Institute (IMSS), Mexico City, México.
Biochem Med (Zagreb) ; 33(2): 020701, 2023 Jun 15.
Article in English | MEDLINE | ID: covidwho-2317187
ABSTRACT

Introduction:

COVID-19 and vaccination may affect some parameters of the complete blood count (CBC). The aim of this study was to determine reference intervals (RI) of CBC in healthy population with different COVID-19 and vaccination backgrounds and compare them with those established previously. Materials and

methods:

A cross-sectional study was conducted in donors who attended the Traumatology Hospital "Dr. Victorio de la Fuente Narváez" (HTVFN) from June to September 2021. Reference intervals were established using the non-parametric method on Sysmex XN-1000. For differences between groups with different COVID-19 and vaccination backgrounds, non-parametric tests were used.

Results:

The RI were established in 156 men and 128 women. Haemoglobin (Hb), haematocrit (Hct), red blood cells (RBC), platelets (Plt), mean platelets volume (MPV), monocytes and relative neutrophils were higher in men than women (P < 0.001). The percentiles of Hb, Hct, RBC, MPV and relative monocytes showed higher values; Plt, white blood cells (WBC), lymphocytes, monocytes, neutrophils, eosinophils and absolute basophils, the 2.5th was higher and the 97.5th was lower; for lymphocytes and relative neutrophils, both percentiles had a trend toward lower values, compared to previous RI. Differences between groups with different COVID-19 and vaccination backgrounds, in lymphocytes (P = 0.038), neutrophils (P = 0.017) and eosinophils (P = 0.018) in men; Hct (P = 0.014), RDW (P = 0.023) in women and MPV (P = 0.001) in both, were not considered pathological.

Conclusions:

The RI for the CBC were established in a Mestizo-Mexican population with different COVID-19 and vaccination backgrounds, so should be updated and validated in different hospitals close to the HTVFN that use the same analyser.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Female / Humans / Male Language: English Journal: Biochem Med (Zagreb) Year: 2023 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Female / Humans / Male Language: English Journal: Biochem Med (Zagreb) Year: 2023 Document Type: Article