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Spotlight on the impact of viral infections on Hematopoietic Stem Cells (HSCs) with a focus on COVID-19 effects.
Nasiri, Kamyar; Mohammadzadehsaliani, Saman; Kheradjoo, Hadis; Shabestari, Alireza Mohammadzadeh; Eshaghizadeh, Parisa; Pakmehr, Azin; Alsaffar, Marwa Fadhil; Al-Naqeeb, Bashar Zuhair Talib; Yasamineh, Saman; Gholizadeh, Omid.
  • Nasiri K; Department of Dentistry, Islamic Azad University, Tehran, Iran.
  • Mohammadzadehsaliani S; Ophthalmology Department, Buraimi Hospital, Buraimi, Oman.
  • Kheradjoo H; Laboratory Department, Buraimi Hospital, Buraimi, Oman.
  • Shabestari AM; Department of Dental Surgery, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Eshaghizadeh P; Department of Dental Surgery, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Pakmehr A; Medical Doctor, Tehran University of Medical Science, Tehran, Iran.
  • Alsaffar MF; Medical Laboratories Techniques Department / AL-Mustaqbal University College, 51001, Hillah, Babil, Iraq.
  • Al-Naqeeb BZT; Anesthesia Technology Department, Al-Turath University College, Al Mansour, Baghdad, Iraq.
  • Yasamineh S; Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran. yassaman124@gmail.com.
  • Gholizadeh O; Department of Bacteriology and Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. ogholizade1374@gmail.com.
Cell Commun Signal ; 21(1): 103, 2023 05 08.
Article in English | MEDLINE | ID: covidwho-2317587
ABSTRACT
Hematopoietic stem cells (HSCs) are known for their significant capability to reconstitute and preserve a functional hematopoietic system in long-term periods after transplantation into conditioned hosts. HSCs are thus crucial cellular targets for the continual repair of inherited hematologic, metabolic, and immunologic disorders. In addition, HSCs can undergo various fates, such as apoptosis, quiescence, migration, differentiation, and self-renewal. Viruses continuously pose a remarkable health risk and request an appropriate, balanced reaction from our immune system, which as well as affects the bone marrow (BM). Therefore, disruption of the hematopoietic system due to viral infection is essential. In addition, patients for whom the risk-to-benefit ratio of HSC transplantation (HSCT) is acceptable have seen an increase in the use of HSCT in recent years. Hematopoietic suppression, BM failure, and HSC exhaustion are all linked to chronic viral infections. Virus infections continue to be a leading cause of morbidity and mortality in HSCT recipients, despite recent advancements in the field. Furthermore, whereas COVID-19 manifests initially as an infection of the respiratory tract, it is now understood to be a systemic illness that significantly impacts the hematological system. Patients with advanced COVID-19 often have thrombocytopenia and blood hypercoagulability. In the era of COVID-19, Hematological manifestations of COVID-19 (i.e., thrombocytopenia and lymphopenia), the immune response, and HSCT may all be affected by the SARS-CoV-2 virus in various ways. Therefore, it is important to determine whether exposure to viral infections may affect HSCs used for HSCT, as this, in turn, may affect engraftment efficiency. In this article, we reviewed the features of HSCs, and the effects of viral infections on HSCs and HSCT, such as SARS-CoV-2, HIV, cytomegalovirus, Epstein-Barr virus, HIV, etc. Video Abstract.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombocytopenia / Virus Diseases / HIV Infections / Epstein-Barr Virus Infections / COVID-19 Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: Cell Commun Signal Year: 2023 Document Type: Article Affiliation country: S12964-023-01122-3

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombocytopenia / Virus Diseases / HIV Infections / Epstein-Barr Virus Infections / COVID-19 Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: Cell Commun Signal Year: 2023 Document Type: Article Affiliation country: S12964-023-01122-3