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Biologic Mechanisms of Macrophage Phenotypes Responding to Infection and the Novel Therapies to Moderate Inflammation.
Ni, Renhao; Jiang, Lingjing; Zhang, Chaohai; Liu, Mujie; Luo, Yang; Hu, Zeming; Mou, Xianbo; Zhu, Yabin.
  • Ni R; Health Science Center, Ningbo University, Ningbo 315211, China.
  • Jiang L; Health Science Center, Ningbo University, Ningbo 315211, China.
  • Zhang C; Health Science Center, Ningbo University, Ningbo 315211, China.
  • Liu M; Health Science Center, Ningbo University, Ningbo 315211, China.
  • Luo Y; Health Science Center, Ningbo University, Ningbo 315211, China.
  • Hu Z; Health Science Center, Ningbo University, Ningbo 315211, China.
  • Mou X; Health Science Center, Ningbo University, Ningbo 315211, China.
  • Zhu Y; Health Science Center, Ningbo University, Ningbo 315211, China.
Int J Mol Sci ; 24(9)2023 May 06.
Article in English | MEDLINE | ID: covidwho-2317682
ABSTRACT
Pro-inflammatory and anti-inflammatory types are the main phenotypes of the macrophage, which are commonly notified as M1 and M2, respectively. The alteration of macrophage phenotypes and the progression of inflammation are intimately associated; both phenotypes usually coexist throughout the whole inflammation stage, involving the transduction of intracellular signals and the secretion of extracellular cytokines. This paper aims to address the interaction of macrophages and surrounding cells and tissues with inflammation-related diseases and clarify the crosstalk of signal pathways relevant to the phenotypic metamorphosis of macrophages. On these bases, some novel therapeutic methods are proposed for regulating inflammation through monitoring the transition of macrophage phenotypes so as to prevent the negative effects of antibiotic drugs utilized in the long term in the clinic. This information will be quite beneficial for the diagnosis and treatment of inflammation-related diseases like pneumonia and other disorders involving macrophages.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Biological Products / Macrophages Limits: Humans Language: English Year: 2023 Document Type: Article Affiliation country: Ijms24098358

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Biological Products / Macrophages Limits: Humans Language: English Year: 2023 Document Type: Article Affiliation country: Ijms24098358