Coagulopathy: A Vicious Indicator of COVID-19
International Journal of Research in Pharmaceutical Sciences
; 11(spl1):1914-1917, 2020.
Article
in English
| EMBASE | ID: covidwho-2318077
ABSTRACT
COVID-19 is routinely associated with coagulopathy and complications associated with thrombosis. However, the difference between the coagulopathy, which is associated with COVID-19 and the coagulopathy, which is due to different causes, is that the "COVID-19 associated coagulopathy" shows raised levels of D-Dimer and that of fibrinogen. However, it shows quite some abnormalities in the levels of prothrombin time and also in the platelet count. "Venous thromboembolism" and arterial thrombosis is frequently seen in COVID-19 associated coagulopathy as opposed to "disseminated intravascular coagulopathy". Patients suffering from COVID-19 have many have multiple factors in common for thromboembolism which is associated with "Adult respiratory distress syndrome" from different etiologies like generalized inflammation and being unambulatory. "Cytokine storm" is the hallmark of COVID-19 associated coagulopathy which is distinguished by high levels of IL-6,1, tumour necrosis factor and other cytokines. The clinical features of COVID-19 associated coagulopathy overlap that of some syndromes like antiphos-pholipid syndrome and thrombotic microangiopathy. Studies have shown that patients diagnosed with disseminated intravascular coagulation have a poor prognosis compared to the one's that don't get diagnosed with DIC. The advancement of the condition from coagulopathy in the vasculature of the lungs to DIC in patients who have tested positive for COVID-19 shows that the patient's dysfunction associated with coagulation has evolved from local to generalized state. Investigating the coagulopathies will help in understanding the mechanism of COVID-19 associated coagulopathy.Copyright © International Journal of Research in Pharmaceutical Sciences.
Coagulopathy; covid-19; Novel Coronavirus; SARS-CoV-2; adult; adult respiratory distress syndrome; artery thrombosis; article; blood clotting disorder; clinical feature; complication; controlled study; coronavirus disease 2019; COVID-19-associated coagulopathy; cytokine storm; disseminated intravascular clotting; gene expression; human; inflammation; nonhuman; platelet count; prognosis; protein expression; prothrombin time; Severe acute respiratory syndrome coronavirus 2; thromboembolism; thrombosis; thrombotic microangiopathy; vascularization; venous thromboembolism; aluminum hydroxide; cytokine; D dimer; endogenous compound; fibrinogen; interleukin 1; interleukin 6; tumor necrosis factor
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Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
International Journal of Research in Pharmaceutical Sciences
Year:
2020
Document Type:
Article
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