Investigation of the Antiviral Effects of Saussurea lappa Root Extract against SARS-CoV-2 Virus.
Mol Nutr Food Res
; : e2200804, 2023 May 11.
Article
in English
| MEDLINE | ID: covidwho-2318245
ABSTRACT
SCOPE The purpose of this study was to look into the antiviral activity of a plant extract derived from the roots of the Saussurea lappa as a food supplement against SARS-CoV-2 infection. METHODS AND RESULTS:
Vero E6 cells are employed in the study to test the neutralizing effect of Saussurea lappa extract against the SARS-CoV-2 virus. For anti-viral activity detection, a sensitive real-time cell analyzer (xCELLigence RTCA) with a high repetition rate is used. A challenge experiment in mice is planned as a result of the in vitro analysis. A challenge test against SARS-CoV-2 is performed with 10 adult female K18-hACE2 transgenic mice in each group for this purpose. The mice in the S. lappa Group are gavaged 2 days before the virus is administered intranasally (i.n.). The control group received PBS instead of the extract. SARS-CoV-2 virus is administered i.n. under anesthesia for the first 3 days of the experiment, and S. lappa extract was administered by gavage in the afternoon. On the 10th day, mice in the S. lappa group survived the study, whereas animals in the control group grew ill and/or died. In this study, the extract protects the mice against the SARS-CoV-2 virus in 90% of the cases.CONCLUSIONS:
This study demonstrates that the Saussurea plant has antiviral effects against SARS-CoV-2 in vitro and in animal models.
Full text:
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Collection:
International databases
Database:
MEDLINE
Type of study:
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
Language:
English
Journal:
Mol Nutr Food Res
Journal subject:
Nutritional Sciences
Year:
2023
Document Type:
Article
Affiliation country:
Mnfr.202200804
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