Alternative structures of RNA control gene expression and offer therapeutic strategies
Journal of Biological Chemistry
; 299(3 Supplement):S687, 2023.
Article
in English
| EMBASE | ID: covidwho-2318717
ABSTRACT
RNA viruses are diverse and abundant pathogens responsible for numerous human ailments, from common colds to AIDS, SARS, Ebola, and other dangerous diseases. RNA viruses possess relatively compact genomes and have therefore evolved multiple mechanisms to maximize their coding capacities, often using overlapping reading frames. In this way, one RNA sequence can encode multiple proteins via mechanisms including alternative splicing and ribosomal frameshifting. Many such processes in gene expression involve the RNA folding into three-dimensional structures that can recruit ribosomes without initiation factors, hijack host proteins, cause ribosomes to frameshift, and expose or occlude regulatory protein binding motifs to ultimately control each key process in the viral life cycle. I will discuss the RNA structure of HIV-1 and SARS-CoV-2 and the importance of alternative conformations assumed by the same RNA sequence in controlling gene expression of viruses and bacteria.Copyright © 2023 The American Society for Biochemistry and Molecular Biology, Inc.
acquired immune deficiency syndrome; alternative RNA splicing; common cold; conference abstract; Ebola hemorrhagic fever; frameshift mutation; gene expression; gene sequence; human; Human immunodeficiency virus 1; infectious agent; life cycle; nonhuman; protein conformation; protein expression; protein function; ribosomal frameshifting; ribosome; RNA folding; RNA sequence; RNA structure; RNA virus; severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; endogenous compound; regulator protein
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Journal of Biological Chemistry
Year:
2023
Document Type:
Article
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