The Evaluation of Hematological Parameters and Their Correlation with Disease Prognosis in COVID-19 Disease in Iran
International Journal of Hematology-Oncology and Stem Cell Research
; 17(2):89-99, 2023.
Article
in English
| EMBASE | ID: covidwho-2319170
ABSTRACT
Background:
Since 2019, Coronavirus has been a highly contagious disease. The COVID-19 outbreak was declared a pandemic by the World Health Organization in March 2020. Variable laboratory findings are reported in COVID-19 patients, among which elevated levels of D-dimer, lactate dehydrogenase, as well as lymphopenia, have been reported to be associated with increased severity of disease symptoms requiring ventilator support, intensive care unit admission, and mortality. Material(s) and Method(s) In the current study, inclusion criteria were patient age above 18 years and hospitalization in the Imam Khomeini hospital with COVID-19 disease confirmed with nasopharyngeal swab polymerase chain reaction tests. Levels of white blood cells, neutrophils, lymphocytes, hemoglobin, platelets, D-dimer, C-reactive protein, LDH, and ferritin were measured and their correlation with the final patients' outcome was evaluated. Result(s) A total of 208 patients were included in the present study. Higher neutrophil to lymphocyte ratio, (WBC count excluding lymphocyte)/lymphocyte, LDH, platelet to lymphocyte ratio, ferritin, and D-dimer were significantly related to O2 dependency. Neutrophil to lymphocyte ratio, (WBC count excluding lymphocyte)/lymphocyte and LDH were significantly related to higher rates of mortality. Higher Hb and lymphocyte count were significantly related to higher rates of survival. Conclusion(s) Hematological parameters including neutrophil to lymphocyte ratio, (WBC count excluding lymphocyte)/lymphocyte, LDH, platelet to lymphocyte ratio, ferritin, D-dimer, Hb, and lymphocyte count were significantly related to the prognosis of patients with COVID-19 disease. This could help decide which COVID-19 patients have priority for hospitalization and intensive medical care, particularly when the pandemic disease causes limitations in healthcare service.Copyright © 2023 Tehran University of Medical Sciences.
covid-19; Disease prognosis; Final outcome; Hematological parameters; ICU admission; adult; article; clinical assessment; controlled study; coronavirus disease 2019; female; ferritin blood level; gene amplification; hospitalization; human; human cell; Iran; leukocyte; leukocyte count; lymphocyte; lymphocyte count; major clinical study; male; medical care; mortality; nasopharyngeal swab; neutrophil; neutrophil lymphocyte ratio; outcome assessment; pandemic; platelet lymphocyte ratio; polymerase chain reaction; prognosis; C reactive protein; D dimer; endogenous compound; ferritin; hemoglobin; oxygen
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
/
Prognostic study
Language:
English
Journal:
International Journal of Hematology-Oncology and Stem Cell Research
Year:
2023
Document Type:
Article
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