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The Optimal Method to Predict Hemoglobin A1c from Flash Glucose Monitor Data
Circulation Conference: American Heart Association's Epidemiology and Prevention/Lifestyle and Cardiometabolic Health ; 145(Supplement 1), 2022.
Article in English | EMBASE | ID: covidwho-2319736
ABSTRACT
In situations where it is difficult for patients to visit hospitals, such as the coronavirus disease pandemic, it is important to more detailly predict hemoglobin A1C (HbA1c) from flash glucose monitor (FGM) data. CGM data over 14 days can be obtained from a FGM sensor;therefore, there are many options for extracting the duration from which glucose levels are derived. Thus, the extracted durations were closely studied to determine which mean glucose levels can predict HbA1c more accurately. Seventy-three outpatients with type 2 diabetes mellitus underwent HbA1c testing, wore a FGM (FreeStyle Libre Pro), and did not change diabetic treatments, on a hospital visit. FGM data over 24 h 13 days (from 0000 on day 2 to 2400 on day 14 [FGM attachment day 1]) were analyzed. The mean glucose levels were calculated corresponding to the following durations 1 day day 2 ~ day 14 (n=13), 2 days days 2-3 ~ days 13-14 (n=12) 12 days days 2-13 ~ days 3-14 (n=2), 13 days days 2-14 (n=1) [total 91 durations] (extracted mean glucose levels). Data were analyzed in all patients (n=73), in patients with hypoglycemia in the 13 days (Hypo) group (n=40), and in patients without hypoglycemia in the 13 days (Nonhypo) group (n=33). In all patients, HbA1c was correlated to all 91 extracted mean glucose levels (r=0.76-0.86, p<0.001). HbA1c was the most significantly correlated to the mean glucose levels over 13 days (days 2-14). "Correlation coefficients between HbA1c and extracted mean glucose levels" ("r, HbA1c, EMGL") were also correlated to number of extracted days for the extracted mean glucose levels (r=0.80, p<0.001 [n=91]). In the Hypo group, HbA1c was correlated to all 91 extracted mean glucose levels (r=0.55-0.73, p<0.001). The mean glucose levels over 13 days (days 2-14) were the most significantly correlated to HbA1c. "r, HbA1c, EMGL" correlated to the number of extracted days for the extracted mean glucose levels (r=0.68, p<0.001;Fig. 2). In the Nonhypo group, HbA1c was correlated to all 91 extracted mean glucose levels (r=0.73-0.87, p<0.001). The mean glucose levels over 12 days (days 2-13) were the most significantly correlated to HbA1c. "r, HbA1c, EMGL" correlated to the number of extracted days for the extracted mean glucose levels (r=0.61, p<0.001). The results of the present study are consistent with that of a previous study reporting that the minimum duration needed to estimate time in range over 90 days is 14 days. In the prediction of HbA1c using data from one FGM sensor, prolonged measurement can make the glucose management indicator more accurate. Especially for patients with hypoglycemia, the importance of prolonged measurement may be applicable.
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Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Prognostic study Language: English Journal: Lifestyle and Cardiometabolic Health Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Prognostic study Language: English Journal: Lifestyle and Cardiometabolic Health Year: 2022 Document Type: Article