Effectiveness of the chAdOx1 nCoV-19 vaccine in preventing COVID-19 infection
Indian Journal of Allergy, Asthma & Immunology
; 36(1):23-27, 2023.
Article
in English
| CAB Abstracts | ID: covidwho-2319777
ABSTRACT
AIM:
The study aimed to assess the effectiveness of the ChAdOx1 nCoV-19 vaccine in preventing laboratory-confirmed COVID-19.METHODS:
It was a test-negative, case-control study conducted at Sharda Hospital, Greater Noida, India, between March 2021 and May 2021. An equal number of cases and controls were included in the study after taking proper informed consent. The individuals with positive reverse transcriptase-polymerase chain reaction test reports were taken as cases, whereas those with negative reports were included as controls. Data were analyzed and the groups were compared using multivariable logistic regression to calculate the odds ratio (OR), with adjustment for gender and presence or absence of comorbidities. The effectiveness of vaccine was calculated by the formula (1-adjusted OR) x100%.RESULTS:
On analyzing the data from 560 case-control pairs, the vaccine effectiveness was calculated as 57.46% (95% confidence interval [CI] 53.85-61.02) and 60.09% (95% CI 56.32-63.77) for single dose and two doses, respectively. The effectiveness of complete and single-dose vaccination against the moderate-to-severe disease was calculated as 63.79% (95% CI 58.58-68.77) and 56.19% (95% CI 51.30-61.0), respectively.CONCLUSION:
The ChAdOx1 nCoV-19 vaccine was found to be effective against COVID-19, with protection after two doses being a little more than that after a single dose. It also proved effective in protecting against the severe form of the disease.
Prion; Viral; Bacterial and Fungal Pathogens of Humans [VV210]; Host Resistance and Immunity [HH600]; Non-communicable Human Diseases and Injuries [VV600]; Mathematics and Statistics [ZZ100]; human diseases; coronavirus disease 2019; viral diseases; efficacy; vaccines; vaccination; immunization; health protection; disease prevention; case-control studies; regression analysis; mathematical models; sex; comorbidity; immune sensitization; man; Severe acute respiratory syndrome coronavirus 2; India; Uttar Pradesh; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; Commonwealth of Nations; lower-middle income countries; medium Human Development Index countries; South Asia; Asia; SARS-CoV-2; viral infections
Full text:
Available
Collection:
Databases of international organizations
Database:
CAB Abstracts
Type of study:
Experimental Studies
Topics:
Vaccines
Language:
English
Journal:
Indian Journal of Allergy, Asthma & Immunology
Year:
2023
Document Type:
Article
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