Evaluation of berberine pellet effect on clinical recovery time in COVID-19 outpatients: a pilot clinical trial
Avicenna Journal of Phytomedicine
; 13(3):265-279, 2023.
Article
in English
| CAB Abstracts | ID: covidwho-2319807
ABSTRACT
Objective:
Severe disease onset of COVID-19 may result in alveolar injury and respiratory failure. Apoptosis and inflammation are the main causes of respiratory distress syndrome. Berberine is used in medicine as an analgesic, anti-asthmatic, anti-inflammatory, and antiviral. In the current investigation, the effect of berberine on COVID-19 outpatients was studied. Materials andMethods:
The present clinical trial was performed on 40 outpatients who were randomly assigned to berberine (300 mg, TID, 2 weeks) (n=19) or placebo groups (n=21). Both groups received standard therapy and they were monitored on days 3, 7, and 14 after the beginning of the therapy for clinical symptoms' improvement, quantitative CRP, lymphopenia, CBC, and SpO2. The severity and frequency of these symptoms and the level of the parameters were statistically compared between the two groups.Results:
On days 0, 3, 7, and 14, there was no significant difference between the berberine and placebo groups in the improvement of clinical symptoms (cough, shortness of breath, nausea, loss of smell and taste, diarrhea, dizziness, sore throat, stomachache, body aches, and body temperature), quantitative CRP, lymphopenia, WBC, neutrophils, platelets, or SpO2.Conclusion:
Berberine (300 mg, TID, two weeks) is ineffective in treating COVID-19. More research with a larger sample size is needed to investigate different berberine dosages in other pharmaceutical formulations.
Prion; Viral; Bacterial and Fungal Pathogens of Humans [VV210]; Non-food/Non-feed Plant Products [SS200]; Pesticides and Drugs; Control [HH405]; antioxidant properties; apoptosis; caspase-3; caspases; cell lines; chemical composition; cytotoxicity; DNA; flavonoids; free radicals; gums; healing; in vitro; medicinal plants; neoplasms; nuclei; phenolic compounds; plant composition; plant extracts; wounds; Ferula gummosa; man; plants; Ferula; Apiaceae; Apiales; eudicots; angiosperms; Spermatophyta; eukaryotes; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; caspase-7; anti-oxidant properties; radical scavenging properties; deoxyribonucleic acid; drug plants; medicinal herbs; officinal plants; cancers; cell nuclei; chemical constituents of plants
Full text:
Available
Collection:
Databases of international organizations
Database:
CAB Abstracts
Type of study:
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
Language:
English
Journal:
Avicenna Journal of Phytomedicine
Year:
2023
Document Type:
Article
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