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An observational study on the safety of COVID-19 vaccination in patients with myasthenia gravis.
Wang, H Y; Qiu, L; Ou, C Y; Lin, Z Q; Huang, Z D; Chen, P; Ma, Q; Lu, Y R; Ran, H; Liu, W B.
  • Wang HY; Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
  • Qiu L; Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
  • Ou CY; Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
  • Lin ZQ; Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
  • Huang ZD; Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
  • Chen P; Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
  • Ma Q; Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
  • Lu YR; Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
  • Ran H; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
  • Liu WB; Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China. Liuwb@mail.sysu.edu.cn.
Neurol Sci ; 44(7): 2239-2245, 2023 Jul.
Article in English | MEDLINE | ID: covidwho-2320296
ABSTRACT

OBJECTIVE:

There is concern that the coronavirus disease (COVID-19) vaccine may trigger or worsen autoimmune diseases. The objective of this study was to determine the impacts of COVID-19 vaccination on symptom severity in patients with myasthenia gravis (MG).

METHODS:

A total of 106 enrolled patients with MG who were vaccinated against COVID-19 were followed up, and a questionnaire was used to document in detail the exacerbation of muscle weakness after vaccination and all other uncomfortable reactions after vaccination. Demographic, clinical characteristics, medication, and vaccination data were collected by follow-up interview. The main observation outcome was whether the MG symptoms of patients were exacerbated. The definition of exacerbation is according to the subjective feeling of the patient or a 2-point increase in daily life myasthenia gravis activity score relative to before vaccination, within 30 days after vaccination.

RESULTS:

Of 106 enrolled patients [median age (SD) 41.0 years, 38 (35.8%) men, 53 (50.0%) with generalized MG, 74 (69.8%) positive for acetylcholine receptor antibody, and 21 (19.8%) with accompanying thymoma], muscle weakness symptoms were stable in 102 (96.2%) patients before vaccine inoculation. Muscle weakness worsened in 10 (9.4%) people after vaccination, of which 8 patients reported slight symptom worsening that resolved quickly (within a few days). Two (1.9%) of patients showed serious symptom aggravation that required hospitalization.

CONCLUSION:

Our results suggest that inactivated virus vaccines against COVID-19 may be safe for patients with MG whose condition is stable. Patients with generalized MG may be more likely to develop increased muscle weakness after vaccination.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thymus Neoplasms / COVID-19 Vaccines / COVID-19 / Myasthenia Gravis Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Adult / Female / Humans / Male Language: English Journal: Neurol Sci Journal subject: Neurology Year: 2023 Document Type: Article Affiliation country: S10072-023-06811-y

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thymus Neoplasms / COVID-19 Vaccines / COVID-19 / Myasthenia Gravis Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Adult / Female / Humans / Male Language: English Journal: Neurol Sci Journal subject: Neurology Year: 2023 Document Type: Article Affiliation country: S10072-023-06811-y