Mechanism and evolution of human ACE2 binding by SARS-CoV-2 spike.
Curr Opin Struct Biol
; 81: 102619, 2023 May 15.
Article
in English
| MEDLINE | ID: covidwho-2320503
ABSTRACT
Spike glycoprotein of SARS-CoV-2 mediates viral entry into host cells by facilitating virus attachment and membrane fusion. ACE2 is the main receptor of SARS-CoV-2 and its interaction with spike has shaped the virus' emergence from an animal reservoir and subsequent evolution in the human host. Many structural studies on the spikeACE2 interaction have provided insights into mechanisms driving viral evolution during the on-going pandemic. This review describes the molecular basis of spike binding to ACE2, outlines mechanisms that have optimised this interaction during viral evolution, and suggests directions for future research.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Language:
English
Journal:
Curr Opin Struct Biol
Journal subject:
Molecular Biology
Year:
2023
Document Type:
Article
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