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Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants.
Xie, Yudi; Liu, Lei; Wang, Jue; Zheng, Yaqiong; Luo, Chen; Ni, Wenxu; He, Zhihang; Zhao, Xin; Liu, Yan; He, Yingyu; Zheng, Shangen; Li, Ling; Liu, Zhong.
  • Xie Y; Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China.
  • Liu L; Key Laboratory of Transfusion Adverse Reactions, Chinese Academy of Medical Sciences (CAMS), Chengdu, China.
  • Wang J; General Hospital of Central Theater Command of the PLA, Wuhan, China.
  • Zheng Y; Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China.
  • Luo C; Key Laboratory of Transfusion Adverse Reactions, Chinese Academy of Medical Sciences (CAMS), Chengdu, China.
  • Ni W; General Hospital of Central Theater Command of the PLA, Wuhan, China.
  • He Z; Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China.
  • Zhao X; Key Laboratory of Transfusion Adverse Reactions, Chinese Academy of Medical Sciences (CAMS), Chengdu, China.
  • Liu Y; General Hospital of Central Theater Command of the PLA, Wuhan, China.
  • He Y; Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China.
  • Zheng S; Key Laboratory of Transfusion Adverse Reactions, Chinese Academy of Medical Sciences (CAMS), Chengdu, China.
  • Li L; Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China.
  • Liu Z; Key Laboratory of Transfusion Adverse Reactions, Chinese Academy of Medical Sciences (CAMS), Chengdu, China.
Front Immunol ; 13: 975533, 2022.
Article in English | MEDLINE | ID: covidwho-2320547
ABSTRACT

Background:

COVID-19 has caused a global pandemic and the death toll is increasing. With the coronavirus continuously mutating, Omicron has replaced Delta as the most widely reported variant in the world. Studies have shown that the plasma of some vaccinated people does not neutralize the Omicron variant. However, further studies are needed to determine whether plasma neutralizes Omicron after one- or two-dose vaccine in patients who have recovered from infection with the original strain.

Methods:

The pseudovirus neutralization assays were performed on 64 plasma samples of convalescent COVID-19 patients, which were divided into pre-vaccination group, one-dose vaccinated group and two-dose vaccinated group.

Results:

In the three groups, there were significant reductions of sera neutralizing activity from WT to Delta variant (B.1.617.2), and from WT to Omicron variant (B.1.1.529) (ps<0.001), but the difference between Delta and Omicron variants were not significant (p>0.05). The average neutralization of the Omicron variant showed a significant difference between pre-vaccination and two-dose vaccinated convalescent individuals (p<0.01).

Conclusions:

Among the 64 plasma samples of COVID-19 convalescents, whether vaccinated or not, Omicron (B.1.1.529) escaped the neutralizing antibodies, with a significantly decreased neutralization activity compared to WT. And two-dose of vaccine could significantly raise the average neutralization of Omicron in convalescent individuals.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / COVID-19 Type of study: Experimental Studies / Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.975533

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / COVID-19 Type of study: Experimental Studies / Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.975533