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A Case of Autoimmune Pulmonary Alveolar Proteinosis that Improved after a COVID-19 Episode.
Yanagisawa, Atsushi; Takimoto, Takayuki; Shintani, Ryota; Kobayashi, Takehiko; Hirose, Masaki; Arai, Toru; Inoue, Yoshikazu.
  • Yanagisawa A; Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan.
  • Takimoto T; Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan.
  • Shintani R; Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan.
  • Kobayashi T; Department of Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan.
  • Hirose M; Department of Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan.
  • Arai T; Department of Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan.
  • Inoue Y; Department of Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan.
Intern Med ; 2023 May 10.
Article in English | MEDLINE | ID: covidwho-2320608
ABSTRACT
Autoimmune pulmonary alveolar proteinosis (APAP) is caused by macrophage dysfunction owing to the presence of anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibodies. A 77-year-old man with APAP was referred to our hospital for whole-lung lavage (WLL) due to oxygenation exacerbation and pulmonary shadows. The patient had had coronavirus disease 2019 (COVID-19) during the APAP evaluation before WLL. About three months after COVID-19 resolved, his oxygenation and shadow reflecting APAP had obviously improved, thus avoiding the need for WLL. We suspected that the improvement in APAP was due to various immunological reactions induced by COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Language: English Journal subject: Internal Medicine Year: 2023 Document Type: Article Affiliation country: Internalmedicine.1592-23

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Language: English Journal subject: Internal Medicine Year: 2023 Document Type: Article Affiliation country: Internalmedicine.1592-23