Role of toll-like receptors in the pathogenesis of COVID-19: Current and future perspectives
Scandinavian Journal of Immunology
; 2023.
Article
in English
| EMBASE | ID: covidwho-2320620
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic underlines a persistent threat of respiratory tract infectious diseases and warrants preparedness for a rapid response. At present, COVID-19 has had a serious social impact and imposed a heavy global burden on public health. The exact pathogenesis of COVID-19 has not been fully elucidated. Since the outbreak of COVID-19, a renewed attention has been brought to Toll-like receptors (TLRs). Available data and new findings have demonstrated that the interaction of human TLRs and SARS-CoV-2 is a vital mediator of COVID-19 immunopathogenesis. TLRs such as TLR2, 4, 7 and 8 are potentially important in viral combat and activation of immunity in patients with COVID-19. Therapeutics targeting TLRs are currently considered promising options against the pandemic. A number of TLR-targeting immunotherapeutics are now being investigated in preclinical studies and different phases of clinical trials. In addition, innovative vaccines based on TLRs under development could be a promising approach for building a new generation of vaccines to solve the current challenges. In this review, we summarize recent progress in the role of TLRs in COVID-19, focusing the new candidate drugs targeting TLRs, the current technology and potential paths forward for employing TLR agonists as vaccine adjuvants.Copyright © 2023 The Scandinavian Foundation for Immunology.
covid-19; SARS-CoV-2; toll-like receptors; vaccine; adult; attention; communicable disease; coronavirus disease 2019; human; immunity; immunopathogenesis; nonhuman; pandemic; preclinical study; protein function; public health; respiratory system; review; Severe acute respiratory syndrome coronavirus 2; endogenous compound; toll like receptor; toll like receptor 2; toll like receptor 4; toll like receptor 7; toll like receptor 8; toll like receptor agonist; vaccine adjuvant
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Scandinavian Journal of Immunology
Year:
2023
Document Type:
Article
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