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Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2.
Yang, Pei-Pei; Ye, Xin-Wei; Liu, Mei-Qin; Yang, Jin-Xuan; Feng, Xiao-Li; Li, Yi-Jing; Zhang, Kuo; Liang, Hong-Wen; Yi, Yu; Wang, Lei; Liu, Yi-Xuan; Yang, Xing-Lou; Shi, Zheng-Li; Feng, Li-Qiang; Chen, Ling; Xue, Yintong; Pan-Hammarström, Qiang; Wang, Hao; Zhao, Yuliang.
  • Yang PP; CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
  • Ye XW; CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
  • Liu MQ; CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
  • Yang JX; Yunnan Key Laboratory of Biodiversity Information, Kunming Institute of Zoology, Chinese Academic of Sciences, Kunming, 650107, China.
  • Feng XL; Kunming National High-level Biosafety Research Center for Non-human Primates, Kunming Institute of Zoology, Chinese Academic of Sciences, Kunming, Yunnan, 650107, China.
  • Li YJ; CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
  • Zhang K; CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
  • Liang HW; CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
  • Yi Y; CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
  • Wang L; CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
  • Liu YX; CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
  • Yang XL; Yunnan Key Laboratory of Biodiversity Information, Kunming Institute of Zoology, Chinese Academic of Sciences, Kunming, 650107, China.
  • Shi ZL; CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
  • Feng LQ; State Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, 511400, China.
  • Chen L; State Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, 511400, China.
  • Xue Y; Department of Immunology, Peking University, Health Science Center, Beijing, 100190, China.
  • Pan-Hammarström Q; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, 14120, Sweden.
  • Wang H; CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
  • Zhao Y; CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
Adv Healthc Mater ; : e2300673, 2023 May 03.
Article in English | MEDLINE | ID: covidwho-2320621
ABSTRACT
The viral spike (S) protein on the surface of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin-converting enzyme 2 (ACE2) receptors on the host cells, facilitating its entry and infection. Here, functionalized nanofibers targeting the S protein with peptide sequences of IRQFFKK, WVHFYHK and NSGGSVH, which are screened from a high-throughput one-bead one-compound screening strategy, are designed and prepared. The flexible nanofibers support multiple binding sites and efficiently entangle SARS-CoV-2, forming a nanofibrous network that blocks the interaction between the S protein of SARS-CoV-2 and the ACE2 on host cells, and efficiently reduce the invasiveness of SARS-CoV-2. In summary, nanofibers entangling represents a smart nanomedicine for the prevention of SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Adv Healthc Mater Year: 2023 Document Type: Article Affiliation country: Adhm.202300673

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Adv Healthc Mater Year: 2023 Document Type: Article Affiliation country: Adhm.202300673